Long story short: I almost got rid of CFS, there is only one thing left to deal with: my cramps which are like kind of myotonia congenita or kind of Benign Fasciculations Syndrome (which is diagnosis for now) or tetany - because it reacts quite well to magnesium.
But the problem is that even though magnesium is good for my muscles it is horrible for my brain.
What happens when I take even a small amount of magnesium, like 100 mgs per day regularly? I feel extremely drowsy (can sleep whole day) and as if I had hangover.
There are two threads here about magnesium making people miserable but my case is different.
Through supplementation, over many years, I discovered that beside magnesium I am oversensitive in a similar way also to:
- taurine
- glycine
- niacin
- niacin riboside
- Valerian
- L-theanine
- GABA - and this one made me feel really terrible and that's when I finally figured out that it must be some kind of GABA oversensitivity.
All of the above substances and magnesium bind to GABA receptor somehow.
The funny thing is that these substances have this bad effect even in very low quantities so this suggests that I have very low quantity or GABA receptors anyway (it seems to me this way but I don't know). The way I feel is thus extremely variable, because I may react very quickly to different supplements.
GABA receptors are supposed to self-regulate ie. if one takes for example niacin for a long time then the number of receptors should lower and the side effects should subside. In other words, my brain should get used to niacin.
Despite my numerous attempts it never worked out as intended.
I had to give up taurine, niacin and magnesium (of course taken on different occasions) when I tried to make my brain more used to it.
What mechanism can be responsible for this and what can I do?
Maybe it's a problem with GABA metabolism (it is not broken down as fast as necessary), maybe it's a problem with glutamate production (perhaps glutamate could counteract some of the GABA actions), maybe there is something else...
What could I take in order to test some hypotheses? Like I could take a supplement that lowers GABA and then take magnesium...
Sidenote: recently I started taking tryptophan and tyrosine and the outcome was just great. So, looks like I may have a problem with delivering aminoacids to the brain.
But the problem is that even though magnesium is good for my muscles it is horrible for my brain.
What happens when I take even a small amount of magnesium, like 100 mgs per day regularly? I feel extremely drowsy (can sleep whole day) and as if I had hangover.
There are two threads here about magnesium making people miserable but my case is different.
Through supplementation, over many years, I discovered that beside magnesium I am oversensitive in a similar way also to:
- taurine
- glycine
- niacin
- niacin riboside
- Valerian
- L-theanine
- GABA - and this one made me feel really terrible and that's when I finally figured out that it must be some kind of GABA oversensitivity.
All of the above substances and magnesium bind to GABA receptor somehow.
The funny thing is that these substances have this bad effect even in very low quantities so this suggests that I have very low quantity or GABA receptors anyway (it seems to me this way but I don't know). The way I feel is thus extremely variable, because I may react very quickly to different supplements.
GABA receptors are supposed to self-regulate ie. if one takes for example niacin for a long time then the number of receptors should lower and the side effects should subside. In other words, my brain should get used to niacin.
Despite my numerous attempts it never worked out as intended.
I had to give up taurine, niacin and magnesium (of course taken on different occasions) when I tried to make my brain more used to it.
What mechanism can be responsible for this and what can I do?
Maybe it's a problem with GABA metabolism (it is not broken down as fast as necessary), maybe it's a problem with glutamate production (perhaps glutamate could counteract some of the GABA actions), maybe there is something else...
What could I take in order to test some hypotheses? Like I could take a supplement that lowers GABA and then take magnesium...
Sidenote: recently I started taking tryptophan and tyrosine and the outcome was just great. So, looks like I may have a problem with delivering aminoacids to the brain.