I had quite a few of those for months. They were initially good at relieving certain symptoms like fatigue and overstimulation but did not cure any underlying problem. In the end I had to give them up because they were affecting my blood pressure, thankfully.
With hindsight I believe they were counterproductive and contributed to setting me up with a huge biofilm problem, which isn't easy to get rid off.
My opinion? Ditch them! (unless you take at the same time some anti-biofilm and antibiotic stuff).