That's interesting. People with fibromyalgia are often prescribed antidepressants because that sometimes helps with the pain. I think increasing norepinephrine, serotonin, and dopamine can all potentially help with the pain. That doesn't mean the pain is psychological although I understand why people can get the wrong idea about that type of treatment and are maybe even hesitant to try it because they think that will give others (including their doctor) the wrong idea about their illness which is physical. Even if there's a neurotransmitter imbalance that doesn't mean the cause isn't physical. There's also Lyrica and Neurontin/gabapentin that act on the GABA receptors, but I think those drugs might involve more than just raising neurotransmitter levels.
I think I probably need more dopamine, but it seems likely that I have too much NE so I haven't tried tyrosine. I know dopamine can convert to norepinephrine though. I'm taking TMG and choline and they potentially can overstimulate the BHMT pathway which would then make it more likely for dopamine to be converted into norepinephrine so I started taking DMG to divert the flow away from the BHMT pathway. I'm hoping the choline will improve my brain fog and some people say cholinergic supplements can have an anxiolytic effect. The TMG is actually in the form of betaine HCL which I'm taking as a digestive enzyme. I'm not taking the choline, DMG, or the TMG (betaine hcl) because they're methyl donors. I wonder if I would be able to tolerate more B12 and methylfolate if I stopped choline and TMG. I'm also planning on starting citicoline and I was thinking it might work better if I was taking choline at the same time. I already have the bottle of citicoline, but I'm waiting to see how the choline works first. I usually buy things on sale, but sometimes wait a few weeks or even a month before I start them. So many things seem to be triggering side effects these days.
