Low thyroid decreases ability to absorb B12 - A study

Beyond

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http://endo.endojournals.org/content/68/4/607.short

Abstract
The absorption of vitamin B12 and the concentrations of vitamin B12 in the plasma and liver were measured in normal rats and in rats in which the thyroid activity was altered. It was found that the absorption of an oral dose of radioactive vitamin B12 is markedly reduced after thyroidectomy and that the thyroid hormone treatment readily normalizes absorption in thyroidectomized rats. However, the administration of intrinsic factor (IF) prepared from rat stomachs did not improve absorption in such animals. The measurement of IF activity in the stomach demonstrated that the amount of IF in the stomach is not reduced in thyroidectomized rats. It seems, therefore, that the thyroidal influence on the absorption of vitamin B-2 is not mediated through the production of IF. A possible hormonal regulation acting directly on the intestinal wall for the absorption of vitamin B12has been discussed.
In the light of so many people here having thyroid issues (I include me) this is some useful information. Anyway, sublingual absorption bypasses this defect. I have low levels of B12 of course, which is no wonder having severe adrenal fatigue and unknown thyroid status (was hypo two years ago, I assume I am much worse now looking at sleep quality).
 
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Beyond

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I will add this which is highly interesting for the methylation folks:
http://www.ncbi.nlm.nih.gov/pubmed/1759094
Abstract
Two adolescent patients suffering from persistent sleep-wake schedule disorders appear to have responded to treatment with vitamin B12 (methylcobalamin). A 15-year-old girl with delayed sleep phase syndrome (DSPS) and a 17-year-old boy with hypernychthemeral syndrome complained of not being able to attend school despite many trials of medication. The improvement of the sleep-wake rhythm disorders appeared immediately after the administration of high doses (3,000 micrograms/day) of methylcobalamin. Neither patient showed any laboratory or clinical evidence of vitamin B12 deficiency or hypothyroidism (which can cause B12 deficiency). Serum concentrations of vitamin B12 during treatment were in the high range of normal or above normal. The duration of the sleep period of the DSPS patient decreased gradually from 10 hours to 7 hours, and the time of sleep onset advanced from 2 a.m. to midnight. The period of the sleep-wake cycle of the hypernychthemeral patient was 24.6 hours before treatment and 24.0 hours after treatment. The relationship between the circadian basis of these disorders and vitamin B12 and its metabolites is discussed.
This adds more evidence to these people who have improved their sleep with B12.
 

MeSci

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http://endo.endojournals.org/content/68/4/607.short



In the light of so many people here having thyroid issues (I include me) this is some useful information. Anyway, sublingual absorption bypasses this defect. I have low levels of B12 of course, which is no wonder having severe adrenal fatigue and unknown thyroid status (was hypo two years ago, I assume I am much worse now looking at sleep quality).
Are you a rat then? :D
 

MeSci

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Haha. Seriosuly, sometimes the studies done in rats have some validity. I think this is the case, since B12 defficiency is common among hypothyroid persons.

http://ecommons.aku.edu/pakistan_fhs_mc_med_diabet_endocrinol_metab/10/?utm_source=ecommons.aku.edu/pakistan_fhs_mc_med_diabet_endocrinol_metab/10&utm_medium=PDF&utm_campaign=PDFCoverPages
I specialised in studying the (in)applicability of studies on non-human animals as models for humans.

The agreement between human results and non-human results is, on average, no better than that from tossing a coin.
 

Beyond

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Yeah but not this time :D I agree though, what´s good of studying things in animals unless we are investigating how to treat animals?