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Abstract
When facing an acute viral infection, our immune systems need to function with finite precision to enable the elimination of the pathogen, whilst protecting our bodies from immune-related damage. In many instances however this "perfect balance" is not achieved, factors such as ageing, cancer, autoimmunity and cardiovascular disease all skew the immune response which is then further distorted by viral infection. In SARS-CoV-2, although the vast majority of COVID-19 cases are mild, as of 24 August 2020, over 800,000 people have died, many from the severe inflammatory cytokine release resulting in extreme clinical manifestations such as acute respiratory distress syndrome (ARDS) and hemophagocytic lymphohistiocytosis (HLH). Severe complications are more common in elderly patients and patients with cardiovascular diseases. Natural killer (NK) cells play a critical role in modulating the immune response and in both of these patient groups, NK cell effector functions are blunted. Preliminary studies in COVID-19 patients with severe disease suggests a reduction in NK cell number and function, resulting in decreased clearance of infected and activated cells, and unchecked elevation of tissue-damaging inflammation markers. SARS-CoV-2 infection skews the immune response towards an overwhelmingly inflammatory phenotype. Restoration of NK cell effector functions has the potential to correct the delicate immune balance required to effectively overcome SARS-CoV-2 infection.
https://pubmed.ncbi.nlm.nih.gov/32883007/
Why isn't low nk function testing being used as a biomarker to diagnose LC and mecfs. Why isn't research putting more effort into ways to increase nk function.
These post viral conditions seem to be leaving people with a nk functional defiency. Maybe this is why they are seeing ebv reactivating in LC patients.
If one has normal nk function but has LC/mecfs they shouldn't be dismissed but it is a test that can help support a diagnosis and maybe treatments.
It does feel like talking to a brick wall but low nk function has been researched and known about for over 30years now. Imagine if they sorted this low nk function 25yrs ago, LC wouldn't be an issue now mostly likely.
When facing an acute viral infection, our immune systems need to function with finite precision to enable the elimination of the pathogen, whilst protecting our bodies from immune-related damage. In many instances however this "perfect balance" is not achieved, factors such as ageing, cancer, autoimmunity and cardiovascular disease all skew the immune response which is then further distorted by viral infection. In SARS-CoV-2, although the vast majority of COVID-19 cases are mild, as of 24 August 2020, over 800,000 people have died, many from the severe inflammatory cytokine release resulting in extreme clinical manifestations such as acute respiratory distress syndrome (ARDS) and hemophagocytic lymphohistiocytosis (HLH). Severe complications are more common in elderly patients and patients with cardiovascular diseases. Natural killer (NK) cells play a critical role in modulating the immune response and in both of these patient groups, NK cell effector functions are blunted. Preliminary studies in COVID-19 patients with severe disease suggests a reduction in NK cell number and function, resulting in decreased clearance of infected and activated cells, and unchecked elevation of tissue-damaging inflammation markers. SARS-CoV-2 infection skews the immune response towards an overwhelmingly inflammatory phenotype. Restoration of NK cell effector functions has the potential to correct the delicate immune balance required to effectively overcome SARS-CoV-2 infection.
https://pubmed.ncbi.nlm.nih.gov/32883007/
Why isn't low nk function testing being used as a biomarker to diagnose LC and mecfs. Why isn't research putting more effort into ways to increase nk function.
These post viral conditions seem to be leaving people with a nk functional defiency. Maybe this is why they are seeing ebv reactivating in LC patients.
If one has normal nk function but has LC/mecfs they shouldn't be dismissed but it is a test that can help support a diagnosis and maybe treatments.
It does feel like talking to a brick wall but low nk function has been researched and known about for over 30years now. Imagine if they sorted this low nk function 25yrs ago, LC wouldn't be an issue now mostly likely.