Long-chain acylcarnitine deficiency in CFS. Potential involvement of altered carnitin

[TheMoonIsBlue]

I was looking up what Carnitine supplements Thorne Research offers (they're one of my fav. brands) there were a few, but one thing caught my eye:

Acetyl-L-Carnitine (Carnityl, brand name) "............Other studies have shown ALC may be of benefit for maintaining a positive mood in the elderly, possibly by partially inhibiting the activity of the hypothalamic-pituitary-adrenal axis and lowering chronically elevated cortisol levels (which become elevated during stressful situations).*

This may be something to be aware of if a person has chronically LOW cortisol levels.

On the other hand, another product they have which is just called L-Carnitine, it says nothing about lowering Cortisol levels.

So does Acetyl-L-Carnitine act differently than just L-Carnitine in this way, affecting Cortisol?

 

[Dolphin]

I was looking up what Carnitine supplements Thorne Research offers (they're one of my fav. brands) there were a few, but one thing caught my eye:

Acetyl-L-Carnitine (Carnityl, brand name) "............Other studies have shown ALC may be of benefit for maintaining a positive mood in the elderly, possibly by partially inhibiting the activity of the hypothalamic-pituitary-adrenal axis and lowering chronically elevated cortisol levels (which become elevated during stressful situations).*

This may be something to be aware of if a person has chronically LOW cortisol levels.

On the other hand, another product they have which is just called L-Carnitine, it says nothing about lowering Cortisol levels.

So does Acetyl-L-Carnitine act differently than just L-Carnitine in this way, affecting Cortisol?

FWIW, not sure I recall talk about carnitine and cortisol. That statement doesn't look very definite. Possibly best to look at scientific research if anyone has time.
I don't have time to look through the PubMed results for cortisol carnitine.
One I see is:

Clin Neuropharmacol. 1988 Oct;11(5):472-7.
Acetyl-L-carnitine acutely administered raises beta-endorphin and cortisol plasma levels in humans.
Martignoni E, Facchinetti F, Sances G, Petraglia F, Nappi G, Genazzani AR.
Department of Neurology, C. Mondino Foundation, University of Pavia, Italy.

but I only looked at two.

 

[alice1]

glenp have you tried supplements plus.I have l-carnitine so I know we can get it here in Canada.

 

[glenp]

Hi, Canadians; Acetyl l-Carnitine is available in Canada, but only as a prescription drug--at very high price--I paid over $100 for I think 100 capsules of 500 mg. each. Your doctor may or may not be familiar with the stuff... Mine was not. The deal was reached apparently between a previous minister of health and a drug company. This is the world we live in, and it will get worse, not better, with the pressure from Codex Alimentarium.. Chris

Thank you Chris - I am going to ask my doctor for a prescription rather then taking the undated product that am able to get here

Just a reminder to everyone, there are various forms of carnitine- the one I and Chris mentioned is Acetyl-l-carnitine - now available as Chris mentioned with a prescription in Canada -

http://www.youtube.com/watch?v=c-M74lgldVw

Side effects

http://www.youtube.com/watch?v=QBzhWjA0YaI&NR=1&feature=fvwp

 

[omerbasket]

Sorry for bringing it up - but I wondered: How/Where can I buy a supplement that would include the ingredients that they found to be deficient in ME/CFS patients, like Oleyl-L-Carnitine and Linoleyl-L-Carnitine, as opposed to L-Carnitine and Acetyl-L-Carnitine, which, in their study, were not downregulated?

If someone has an answer, I'd be glad to hear (or read...) it