Learn about series- Apoptosis aka programmed cell death, why and how this happens and its relationship to the Endogenous Cannabinoid System.

CSMLSM

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Here I will post links to videos that explain the process of apoptosis, why it is a vital process in the body and also how the Endogenous Cannabinoid System is involved in its regulation.

Daniel
 

CSMLSM

Senior Member
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267
Apoptosis: Programmed Cell Death - YouTube

Professor Dave Explains Feb 26, 2020 6.28min

We've touched on apoptosis before, especially when we learned about cancer in the biochemistry series. But let's a closer look. We know that apoptosis is programmed cell death, a failsafe mechanism whereby faulty cells that pose a threat to an organism can be systematically destroyed. How does this work? Where do the signals come from and how do they propagate? What kinds of proteins are involved in carrying out this activity? Come and see! Watch the whole Biology/Genetics playlist: http://bit.ly/ProfDaveBio
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CSMLSM

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Patient reports on the paper- Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression (nih.gov)

Abstract
Cannabinoids are a group of compounds present in Cannabis plant (Cannabis sativa L.). They mediate their physiological and behavioral effects by activating specific cannabinoid receptors. With the recent discovery of the cannabinoid receptors (CB1 and CB2) and the endocannabinoid system, research in this field has expanded exponentially. Cannabinoids have been shown to act as potent immunosuppressive and anti-inflammatory agents and have been shown to mediate beneficial effects in a wide range of immune-mediated diseases such as multiple sclerosis, diabetes, septic shock, rheumatoid arthritis, and allergic asthma. Cannabinoid receptor 1 (CB1) is mainly expressed on the cells of the central nervous system as well as in the periphery. In contrast, cannabinoid receptor 2 (CB2) is predominantly expressed on immune cells. The precise mechanisms through which cannabinoids mediate immunosuppression is only now beginning to be understood and can be broadly categorized into four pathways: apoptosis, inhibition of proliferation, suppression of cytokine and chemokine production and induction of T regulatory cells (T regs). Studies from our laboratory have focused on mechanisms of apoptosis induction by natural and synthetic cannabinoids through activation of CB2 receptors. In this review, we will focus on apoptotic mechanisms of immunosuppression mediated by cannabinoids on different immune cell populations and discuss how activation of CB2 provides a novel therapeutic modality against inflammatory and autoimmune diseases as well as malignancies of the immune system, without exerting the untoward psychotropic effects.


Cannabinoid Induced Apoptosis - YouTube

The Pot Scientist Reports Feb 19, 2019 8.10min

Here is the link to the CED Foundation:

https://www.cedfoundation.com/
 

CSMLSM

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What is Necrosis vs What is Apoptosis? - YouTube

FreeMedEducation May 27, 2018 4.43min

Animated Video explaining in detail the differences between Necrosis and Apoptosis. A project of
Free Medical Education.
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#FreeMedicalEducation #Necrosis #Apoptosis
 
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