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LDN Issues?


Senior Member
So occasionally i get mild white coat hypertension. But recently I got some readings that were high even for me (above 140/80) They happened on days on which I'd taken low dose naltrexone, which does make me feel really stimulated.

I assumed LDN was really really benign because it's just naltrexone but in lower doses, but I think that since it could have a wholly different effect than high doses (i.e. partial blockade of opioid receptors causing upregulation of density) caution is warranted. I don't want to get a home bp monitor because I think I would be more hypochondriac with it, but I may, just so I can check if the naltrexone makes a difference. It's helped my fatigue, but I don't want it to mess with my health.

Has anyone else experienced issues like this with naltrexone?


Forum Support Assistant
I have consistenly low BP (average is 80/50 lying, 90/60 standing). The only time LDN has influenced my BP was when I tried yohimbe. Yohimbe by itself raises BP but when combined with LDN my BP fluctuated frequently for a couple of hours. I've read that this effect is common when combining yohimbe with LDN.