Could you please explain more about not producing enough endorphins and experiencing depression. I am having a very difficult time with LDN. If I take it more than once/week I experience depression. However, everytime I go off it for a while (say three weeks) I experience a great sense of well being after the first couple of days of taking LDN. Unfortunately ,after those first couple of days, my system spirals back to depression and anxiety which I never experienced before LDN. I am wondering if it is maybe not the drug for me.
Why not join us on the LDN thread:
You don't say how much you are taking. The motto for LDN seems to "low and slow". That is, many people with ME/CFS need to start at really low doses, like only 1mg, or even less in some cases, and to raise the dose very, very slowly.
Regards the statement that you have to be off pain meds for 2 weeks before starting LDN, that applies only to opiates, not other types of pain meds. LDN does not increase pain, in any case, it just makes opiates ineffective for several hours a day, while it is blocking the opiate receptors.
Dr Bilary has also said, more recently, that you can take it whenever it works best for you, as some people seem to have their nights and days reversed. So, some users who felt too wired to sleep at night take it in the morning and have more energy during the day, then sleep better at night.
For me, the biggest and best improvement I have felt is that I now sleep without sleep meds, sleep in a more normal way and wake up more normally, feeling in a good mood. Come join us on the LDN thread and post your questions. Maybe others have had similar experiences to yours.