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Latest Research out of OMF

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40
This is what I received in my email from The Open Medicine Foundation - a new research study has just been published on Red Blood Cells and ME/CFS. I have attached the synopsis below. It is VERY exciting! It looks like they may have a biomarker/diagnostic test soon!

Study:
https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch180469


OMF-funded Red Blood Cell Deformability Research Study Published
Written by Ronald W. Davis, PhD

This paper documents that red blood cells are less deformable in ME/CFS patients compared to healthy controls. It potentially could be a biomarker, and we are proceeding to design new devices that will make a clear distinction between patients and healthy controls. These devices will be hand-held and easy to use by doctors in their offices, or in clinical testing labs. Past work has looked primarily at the shape of red blood cells, which is difficult to quantitate. Our approach will give a clear quantitative number. It measures the ability of red blood cells to deform while squeezing into a capillary, something that blood cells must do for healthy flow. We measure hundreds of cells from each patient, so, because of this, even though the number of patients is low, we get a very statistically significant distinction between patient and healthy cells' deformability. We are putting our energy into developing the new devices as soon as possible.
 

halcyon

Senior Member
Messages
2,482
Past work has looked primarily at the shape of red blood cells, which is difficult to quantitate.
That’s actually not true. The past work measured blood filterability using rheological techniques and determined that (acute female) ME blood filtered poorly.

I thought it a strange omission that Les Simpson’s research was not referenced in the paper, but now I’m wondering if Ron has even read the research at all.
 
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taniaaust1

Senior Member
Messages
13,054
Location
Sth Australia
@halcyon there has been some, or at least one, which looked at the shape o the red blood cells. I may not be remembering that finding properly but I think it was that we had larger ones. This was also a finding of my ME/CFS sisters blood who had an gov accredited Naturopath closely look at it under a microscope.
 

halcyon

Senior Member
Messages
2,482
@halcyon there has been some, or at least one, which looked at the shape o the red blood cells. I may not be remembering that finding properly but I think it was that we had larger ones. This was also a finding of my ME/CFS sisters blood who had an gov accredited Naturopath closely look at it under a microscope.
Les Simpson’s later research shifted to looking at red cell shape, but his initial published work was on measuring the actual flow of the blood. The two are hypothetically related; the increased number of abnormal cup shaped cells are thought to have poor membrane deformability, which then causes the blood to flow poorly through the microcirculation.
 

Tally

Senior Member
Messages
367
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Messages
25
We measure hundreds of cells from each patient, so, because of this, even though the number of patients is low, we get a very statistically significant distinction between patient and healthy cells' deformability.

But if the number of patients is low, you still can't know for sure if this holds for all patients right? Maybe the patients tested are only a subset.