Lancet publishes study on SIM01 in long covid

[consuegra]

This from Lancet regarding a study on SIM01 and Long Covid published from China lab

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00685-0/fulltext

 

[Rufous McKinney]

Here is a previous paper where they discuss whats SIMO1 is:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115073/

This was an open‐label, proof‐of‐concept study. Consecutive COVID‐19 patients admitted to an infectious disease referral center in Hong Kong were given a novel formula of

Bifidobacteria strains,

galactooligosaccharides,

xylooligosaccharide, and

resistant dextrin (SIM01).

 

[consuegra]

What interests me is the micro-encapsulation of three bifidobacterium and claims that these items reach the gut and colonize. I wonder if this is true? This Lancet publication of this Chinese study gives some specific credibility to SIM01. This formulation of SIM01 seems slightly different than other probiotics, especially Bifidobacteria products. Being able to raise Bifidobacteria in the gut is notoriously difficult. Seems a big deal if this would work. I suppose the best way to find out is to give it a try.

Chris

 

[Atlas]

The marketing page for SIM01.

Apparently they used AI to select the strains, and it is being marketed as tailored to the microbiome of people from Asia.


The placebo effect in the study seems quite large... it does seem to be consistently better than placebo, but not as large a gain as from the placebo effect itself.

 

[consuegra]

From the Lancet publication

"The synbiotic preparation (SIM01) is a micro-encapsulated lyophilised powder containing 20 billion colony-forming units of three bacterial strains, B adolescentis, Bifidobacterium bifidum, and Bifidobacterium longum with three prebiotic compounds including galacto-oligosaccharides, xylo-oligosaccharides, and resistant dextrin, which has been shown to promote the growth of these bacterial strains but also other probiotic strains.

The specific ratio of the three probiotic bacteria was decided based on the relative abundance of these species naturally present in the healthy Chinese population. We previously found that the relative abundance of several species, including B adolescentis and B longum, and the bacterial pathway of short-chain fatty acid production, were all significantly lower in the gut of COVID-19 patients compared with healthy individuals."

The key seems to be the micro-encapsulated lyophilized powder. Bifodobactium species seem to be somewhat predictable.

If this raises bifidcobacterium in gut, that would be helpful

Chris

 

[godlovesatrier]

They do colonize but not forever, you're talking maybe a month. I highly doubt that it colonizes long term, that would be a major scientific finding. I see vivomixx strains on my 16s for about 1 to 2 months, then they disappear.

 

[Rufous McKinney]

I highly doubt that it colonizes long term,

so where are we to obtain, over time, this organism that does not stick around?

what is the natural source of this critter?

 

[godlovesatrier]

Depends on the strains used I haven't seen them mention that in the study paper myself. Just the species used, not the strains. So without taht info it's anyone's guess to be honest.

Life extension do https://www.lifeextensioneurope.co.uk/bifido-gi-balance which is longum bb536

Another very good longum branded probiotic: https://uk.iherb.com/pr/align-probi...k6ogGkz5ugR3pIEpaOIW_bJWFbjTQ0cPGTUwFDnd2IraM

https://www.metabolics.com/bifidobacterium-longum-powder-100g.html

These 3 are all excellent brands and all mention the strain used which is important.

Struggling to find bifidobacterium adolescentis

I found this though which contains a strain of longum and adlescentis: https://uk.iherb.com/pr/nb-pure-poobiotics-60-capsules/120599 but can't tell you if the brand is any good.

Probiotic Blend (10 Billion cfu**)
lactobacillus acidophilus DDS-1®, Bifidobacterium
bifidum UAB-b-10™, Bifidobacterium adolescentis iVS-1®
Bifidobacterium lactis UABla-12™, Bifidobacterium
longum iVE-15®

Never seen these strains before myself.

ive-15 claims (no scientific studies seem to back this up)

• When delivered as a synbiotic with XOS, iVE-15® was able to establish a desirable presence in 18 out of 20 fecal microbiome samples tested​

• iVE-15® achieves a very high (90%) colonization rate​

• Superior consumer of prebiotic XOS​

I don't tolerate these fancy strains of any sort or type, I've tried about 8 now and had bad results throughout, most give me insomnia, others give me bad acid reflux (possible comorbidity for many pwme), but I am sure some of you who have better tolerance may do well on them ​

I do think if I had got on these products earlier in my ME things would have been much different. I think there's a lot of damage in my body which may or may not lift with cessation of viral and bacterial load replication.

 

[Rufous McKinney]

Depends on the strains

I've been using a brand recommended in another PR thread.

Mood Probiotics

1) Lactobacillus helviticus ROSELLE-52N
2)Bifidobacterium longum Roselle-175
'
Also eating alot of fresh and unprocessed foods grown on entirely different none USA soil down the road.

 

[Forummember9922]

Infantis is used by the Remission Biome people, and some other articles below
https://cfsremission.com/2013/08/14/bifidobacterium-infantis-35624-a-demonstrated-probiotic/
https://www.tandfonline.com/doi/full/10.4161/gmic.25487

I think a lot of people will now want to try G-Niib Sim01.
For people like myself in the USA I dont see a clear way to buy this right now

But- It was recently listed on Amazon UK so maybe that's worth watching.
https://www.amazon.co.uk/G-NiiB-Immunity-microbiome-Resistant-Polydextrose/dp/B0CKWH68C6


Personally I was thinking of incorporating something like this until I can get G-Niib
https://www.amazon.com/Garden-Life-Formulated-Probiotics-Postbiotics/dp/B09TG538V8

 

[godlovesatrier]

It depends if the colonization remarks are actually legit or not, also depends on side effects too, most of them have given be bad side effects so far.

 

[Atlas]

Depends on the strains used I haven't seen them mention that in the study paper myself. Just the species used, not the strains.

They are "gut microbiota-derived" strains, that is, they are naturally occurring strains in the gut, which were chosen for this new formula on the basis of an AI analysis of the microbiome of people from China, which had the goal of finding strains which are beneficial regulators of the microbiome.

The species were B adolescentis, Bifidobacterium bifidum, and Bifidobacterium longum. It is not clear how they chose the exact strains of these species, since the strains would surely differ slightly amongst and even within individuals. It appears likely by my reading that the AI analysis must have been based on the species-level bacterial presences.

"The specific ratio of the three probiotic bacteria was decided based on the relative abundance of these species naturally present in the healthy Chinese population. We previously found that the relative abundance of several species, including B adolescentis and B longum, and the bacterial pathway of short-chain fatty acid production, were all significantly lower in the gut of COVID-19 patients compared with healthy individuals"
...
"Using our metagenomics dataset, we found that B adolescentis, B bifidum, and B longum were the species that had the greatest positive correlations with the relative abundance of short-chain fatty acid-producing bacterial species, which could potentially boost immunity and prevent and treat respiratory infections (unpublished)."

So if the analysis was done at the species level then the exact strains must have been obtained from a healthy individual, but I haven't seen any info on how they decided to select the strains specifically from amongst the species.

 

[godlovesatrier]

Good digging. Yeah it's very vague but interesting. Ken did try to get human intestinal species and tried those but still saw no colonisation. But maybe these do work who knows. It's a very tricky business colonisation.