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Oh, so you have IgG deficiency (in the US we call it CVID)?? Horrendous GI inflammation is actually a side effect of the immune deficiency (I have an igG subclass deficiency for which I get IVIG).
I had really bad diffuse GI tract inflammation that wasn't responding to meds. My GI docs had referred me for surgery, but I happened to mention it to my Immunologist who said it is guidelines to increase my IVIG dose until my GI issues resolve. Well, he did and now I'm off all GI meds and I didnt need surgery.
Regarding side effects of IVIG, they are typically related to the rate of infusion, so if you can't tolerate premedications (typically some NSAID or tylenol vs. a corticosteroid & an antihistamine), they would just have to run yours very very slowly, maybe even split the dose into smaller amounts and infuse every day or two and titration up as tolerated.
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As to why the Vagas nerve stim probably didn't work - it causes it's effects through the very receptor you have antibodies against (a7 nAChR). So if the antibodes are blocking the receptor strongly, Vagas nerve stim won't work.
You would have to use the things I listed that lower TNF-a without using the a7 nAChR: tumeric, Charlotte's Web oil, ecchinacea, MJ, etc.
I had really bad diffuse GI tract inflammation that wasn't responding to meds. My GI docs had referred me for surgery, but I happened to mention it to my Immunologist who said it is guidelines to increase my IVIG dose until my GI issues resolve. Well, he did and now I'm off all GI meds and I didnt need surgery.
Regarding side effects of IVIG, they are typically related to the rate of infusion, so if you can't tolerate premedications (typically some NSAID or tylenol vs. a corticosteroid & an antihistamine), they would just have to run yours very very slowly, maybe even split the dose into smaller amounts and infuse every day or two and titration up as tolerated.
_________________
As to why the Vagas nerve stim probably didn't work - it causes it's effects through the very receptor you have antibodies against (a7 nAChR). So if the antibodes are blocking the receptor strongly, Vagas nerve stim won't work.
You would have to use the things I listed that lower TNF-a without using the a7 nAChR: tumeric, Charlotte's Web oil, ecchinacea, MJ, etc.