That's interesting - I didn't know that drug doses were calculated by initial testing. I had thought doses were calculated in relation to weight only. So the Rituximab dose formula isn't based on testing of Rituximab itself?
BUT, the one thing I would say is that Drs Fluge and Mella are developing the longer term treatment schedule in an extremely intelligent and imaginative way. They are watching exactly what is happening as they go along and adjusting accordingly. It might be possible to get away with a much smaller initial dose but I suspect their follow up doses are pretty much right.