It would be interesting to see what a bone marrow transplant might do for a ME/CFS patient. In reality, this is not going be investigated, because of the severe risks and complications involved in bone marrow transplantation (though I wonder if there have been any cancer patients who also have ME/CFS that have received a bone marrow transplant?)
I do know someone who had ME symptoms but no formal diagnosis (actually a fibromyalgia diagnosis) but definitely had PEM who had a bone marrow transplant for Leukemia (but also followed by Rituximab for post transplant lymphoma) and a lot of other drugs!. The ME symptoms seemed to go including the pain disappeared (I think prior to the Rituximab) the nature of the fatigue changed in that the PEM went.
That's interesting. I guess, though, we would have to be careful about coming to any conclusions, unless it were certain that they had ME/CFS. Leukemia does involve fatigue, so unless they had had ME/CFS for say a decade before the leukemia arose, my thoughts are that the leukemia fatigue could have been mistaken for ME/CFS.
But it would be great to hear some more accounts of ME/CFS disappearing for good after a bone marrow transplant.
The fatigue definitely wasn't initially Leukemia. But her medical history was complex.
Perhaps @Jonathan Edwards might weigh in here, but from reading many areas of science out of my own interest, it always seems that when a scientist is running with a particular hypothesis, they usually try their best to figure out how the observed facts can be explained by their hypothesis. The hypothesis is their baby, and so naturally they work hard to try to make sure it has the best start in life, so to speak.
You can rest assured that many other scientist are going to be skeptical and critical of your hypothesis or theory, so if you don't work to support your hypothesis, nobody else will.