JAK1 Inhibitor Rinvoq Quickly Returns Severely Ill ME/CFS Patient to Health - Parts I and II

MonkeyMan

MonkeyMan

Senior Member
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I did some research on Rinvoq. As others here have pointed out, it's a nasty drug that could put you in the hospital or even 6 feet under if you're not careful.

But Rinvoq has a cousin who is gentler and nicer (i.e., safer), called Sotyktu (deucravacitinib). Sotyktu is indicated for the treatment of psoriasis. With its ability to tamp down an overactive immune system, I wonder if Sotyktu could potentially help some ME/CFS patients?
 
Sushi

Sushi

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MonkeyMan said:
I did some research on Rinvoq. As others here have pointed out, it's a nasty drug that could put you in the hospital or even 6 feet under if you're not careful.
Click to expand...
Yes, much care is needed: lab tests before, regularly during, and then after finishing the protocol—for safety. You need to check that you’re not harboring latent TB for instance before starting. Also, it is important to protect yourself against exposure to any infections, perhaps to take an anticoagulant and things like Lysine and Olive Leaf Extract or other mild anti-virals, anti-fungals for extra protection. It is not a drug to take without your own research and preparation.
 
cfs since 1998

cfs since 1998

Senior Member
Messages
765
MonkeyMan said:
I did some research on Rinvoq. As others here have pointed out, it's a nasty drug that could put you in the hospital or even 6 feet under if you're not careful.

But Rinvoq has a cousin who is gentler and nicer (i.e., safer), called Sotyktu (deucravacitinib). Sotyktu is indicated for the treatment of psoriasis. With its ability to tamp down an overactive immune system, I wonder if Sotyktu could potentially help some ME/CFS patients?
Click to expand...

That is interesting because a genetic allele associated with ME/CFS, HLA-DQB1*03:03(1), is also associated with psoriasis(2,3). A study in Taiwan found psoriasis patients had a 50% increased risk of ME/CFS, but the risk was eliminated when the psoriasis was treated with UV radiation or immunosupressant drugs(4).

References:
(1) Lande A, Fluge Ø, Strand EB, Flåm ST, Sosa DD, Mella O, Egeland T, Saugstad OD, Lie BA, Viken MK. Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Sci Rep. 2020 Mar 24;10(1):5267. doi: 10.1038/s41598-020-62157-x. PMID:32210306; PMCID: PMC7093502.
(2) Ozawa A, Miyahara M, Sugai J, Iizuka M, Kawakubo Y, Matsuo I, Ohkido M, Naruse T, Ando H, Inoko H, Kobayashi H, Ohkawara A, Takahashi H,Iizuka H, Morita E, Yamamoto S, Hide M, Taniguchi Y, Shimizu M. HLA class I and II alleles and susceptibility to generalized pustular psoriasis:significant associations with HLA-Cw1 and HLA-DQB1*0303. J Dermatol. 1998 Sep;25(9):573-81. doi: 10.1111/j.1346-8138.1998.tb02461.x. PMID:9798343.
(3) Cassia FF, Cardoso JF, Porto LC, Ramos-E-Silva M, Carneiro S. Association of HLA Alleles and HLA Haplotypes with Psoriasis, Psoriatic Arthritisand Disease Severity in a Miscegenated Population. Psoriasis (Auckl). 2021 May 10;11:41-51. doi: 10.2147/PTT.S258050. PMID: 34007822; PMCID:pMC8121669.
(4) Tsai SY, Chen HJ, Chen C, Lio CF, Kuo CF, Leong KH, Wang YT, Yang TY, You CH, Wang WS. Increased risk of chronic fatigue syndrome followingpsoriasis: a nationwide population-based cohort study. J Transl Med. 2019 May 14;17(1):154. doi: 10.1186/s12967-019-1888-1. PMID: 31088562;PMCID: PMC6518753.
 
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