Is Sam-E better for methylation than methylfolate or methyl b12?

[drob31]

Is Sam-E better, or just different because it provides Sam?

 

[Learner1]

No, you need all the methylation nutrients. If you just take SAMe, you'll likely end up with too high homocysteine as you'll be missing the needed cofactors to recycle homocysteine back to methionine.