Is Mannose Binding Lectin a TNF-α inhibitor? 2022 study

[pattismith]

Like many CFS patients, I have MBL deficiency (undetectatble in my serum), so this paper caught my eyes.

It suggests that under some circumstances, MBL can stop TNF-α action.

A previous study in 2001 found the same anti-inflammatory effect of MBL.



Mannan-Binding Lectin Deficiency Limits Inflammation-induced Myeloid-Derived Suppressor Cells Expansion via Modulating Tumor Necrosis Factor Alpha-triggered Apoptosis (ijbs.com)

Mannose-Binding Lectin Regulates the Inflammatory Response of Human Professional Phagocytes to Neisseria meningitidis Serogroup B | The Journal of Infectious Diseases | Oxford Academic

 

[Learner1]

@pattismith Interesting topic. Did you mean to have leptin in the title and not lectin?

My MBL is high. Not sure what it means, though....