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Intravenous Vitamin C Administration Reduces Fatigue in Office Workers: 2xBlind RCT

Dolphin

Senior Member
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Free full text: http://www.nutritionj.com/content/pdf/1475-2891-11-7.pdf (provisional)

Intravenous Vitamin C Administration Reduces Fatigue in Office Workers: A Double-blind Randomized Controlled Trial

Sang-Yeon Suh, Woo Kyung Bae, Hong-Yup Ahn, Sung-Eun Choi, Gyou-Chul Jung and Chang Hwan Yeom

Nutrition Journal 2012, 11:7 doi:10.1186/1475-2891-11-7

Published: 20 January 2012

Abstract*

Background

Studies of the efficacy of vitamin C treatment for fatigue have yielded inconsistent results.

One of the reasons for this inconsistency could be the difference in delivery routes.

Therefore, we planned a clinical trial with intravenous vitamin C administration.

Methods:

We evaluated the effect of intravenous vitamin C on fatigue in office workers.

A group of 141 healthy volunteers, aged 20 to 49 years participated in this randomized, double-blind, controlled clinical trial.

The trial group received 10 grams of vitamin C with normal saline intravenously, while the placebo group received normal saline only.

Since vitamin C is a well-known antioxidant, oxidative stress was measured.

Fatigue score, oxidative stress, and plasma vitamin C levels were measured before intervention, and again two hours and one day after intervention.

Adverse events were monitored.

Results:

The fatigue scores measured at two hours after intervention and one day after intervention were significantly different between the two groups (p = 0.004); fatigue scores decreased in the vitamin C group after two hours and remained lower for one day.

Trial also led to higher plasma vitamin C levels and lower oxidative stress compared to the placebo group (p < 0.001, p < 0.001, respectively).

When data analysis was refined by dividing each group into high-baseline and low-baseline subgroups, it was observed that fatigue was reduced in the lower baseline vitamin C level group after two hours and after one day (p = 0.004).

The same did not hold for the higher baseline group (p = 0.206).

Conclusion:

Thus, intravenous vitamin C reduced fatigue at two hours, and the effect persisted for one day.

There were no significant differences in adverse events between two groups.

High dose intravenous vitamin C proved to be safe and effective against fatigue in this study.

The clinical trial registration of this trial is ClinicalTrials.gov NCT00633581.

* I gave each sentence its own paragraph.
Paper has a few Chronic Fatigue Syndrome references.