I have not had IV oxygen therapy however I have had IV ozone therapy which I believe is different but similar action of oxygenating the blood. For me I found it very helpful, it totally stopped my persistent viral symptoms (constant sore throat in the morning, chronic low levels of strep in my blood). Luckily it was another piece of the jigsaw puzzle for me.
Depending on where you are with your ME (mild, mod, severe etc) I would imagine it will have different draining effects, especially if you have any viral issues. For me when I had an ozone session it would instantly stop my brain fog, make me feel really clear and sharp, then would make me a nice sleepy tired in the evenings.
Why did you chose this over hyperbaric oxygen can I ask, is it more intense or has a different effect? Does this therapy have any claims to stimulate mitochondria or is it just an antiviral effect in the blood?
As for high oxidative stress, I recently I found I was +/- for SOD2 and from organic acid tests I know I have higher levels of oxidative stress in my mitochondria yet I was able to benefit from ozone despite this. Perhaps have some antioxidants on standby after your treatment, not straight away but for the following day if you feel rotten. I personally don't see the point of taking antioxidants before the treatment as I imagine they would be working against the IV oxygen. I think it may be trial and error.