pattismith
Senior Member
- Messages
- 3,946
Several articles already noticed similarities between IH and CFS/ME and Fibro.
Hormons play a role in modulating brain liquid production and draining, probably via ion channels activity.
I got myself IH when I was low in fT3, then now I got it from a testosterone supplementation trial.
It was shown that IH is much more prevalent in women, and is associated with different hormonal imbalances:
hypothyroidism
hyperthyroidism
hypogonadism (men)
hyperandrogenism (women)
Glucocorticoids excess or insufficiency (cortisol)
I post again a quote from another thread:
this study just released points an androgen connection as well (in obese women):
A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics
feb 2019
abstract
Idiopathic intracranial hypertension (IIH) is a condition of unknown etiology, characterized by elevated intracranial pressure frequently manifesting with chronic headaches and visual loss. Similar to polycystic ovary syndrome (PCOS), IIH predominantly affects obese women of reproductive age. In this study, we comprehensively examined the systemic and cerebrospinal fluid (CSF) androgen metabolome in women with IIH in comparison with sex-, BMI-, and age-matched control groups with either simple obesity or PCOS (i.e., obesity and androgen excess). Women with IIH showed a pattern of androgen excess distinct to that observed in PCOS and simple obesity, with increased serum testosterone and increased CSF testosterone and androstenedione.
Human choroid plexus expressed the androgen receptor, alongside the androgen-activating enzyme aldoketoreductase type 1C3. We show that in a rat choroid plexus cell line, testosterone significantly enhanced the activity of Na+/K+-ATPase, a surrogate of CSF secretion.
We demonstrate that IIH patients have a unique signature of androgen excess and provide evidence that androgens can modulate CSF secretion via the choroid plexus. These findings implicate androgen excess as a potential causal driver and therapeutic target in IIH.
Hormons play a role in modulating brain liquid production and draining, probably via ion channels activity.
I got myself IH when I was low in fT3, then now I got it from a testosterone supplementation trial.
It was shown that IH is much more prevalent in women, and is associated with different hormonal imbalances:
hypothyroidism
hyperthyroidism
hypogonadism (men)
hyperandrogenism (women)
Glucocorticoids excess or insufficiency (cortisol)
I post again a quote from another thread:
My researches convinced me that this headache/balloon is related to idiopathic intracranial hypertension. (I got two times pulsed tinnitus, which is typical of IIH)
This condition has been described in hypothyroidism, but also associated with testosterone deficiency in men.
Interestingly , it was also described in a case of a woman taking testosterone for transgender transformation:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706971/
this study just released points an androgen connection as well (in obese women):
A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics
feb 2019
abstract
Idiopathic intracranial hypertension (IIH) is a condition of unknown etiology, characterized by elevated intracranial pressure frequently manifesting with chronic headaches and visual loss. Similar to polycystic ovary syndrome (PCOS), IIH predominantly affects obese women of reproductive age. In this study, we comprehensively examined the systemic and cerebrospinal fluid (CSF) androgen metabolome in women with IIH in comparison with sex-, BMI-, and age-matched control groups with either simple obesity or PCOS (i.e., obesity and androgen excess). Women with IIH showed a pattern of androgen excess distinct to that observed in PCOS and simple obesity, with increased serum testosterone and increased CSF testosterone and androstenedione.
Human choroid plexus expressed the androgen receptor, alongside the androgen-activating enzyme aldoketoreductase type 1C3. We show that in a rat choroid plexus cell line, testosterone significantly enhanced the activity of Na+/K+-ATPase, a surrogate of CSF secretion.
We demonstrate that IIH patients have a unique signature of androgen excess and provide evidence that androgens can modulate CSF secretion via the choroid plexus. These findings implicate androgen excess as a potential causal driver and therapeutic target in IIH.
Last edited by a moderator: