Intracellular iron regulation, infections and the effect of LPS endotoxins

[pattismith]

I've been trending a little high - but within range - for blood iron, and low for ferritin. My most recent labs, however, had me out-of-range high for blood iron, and right on the border for out-of-range low ferritin. High iron, low ferritin; both trending in opposite directions.

So, unless I had a one-off lab error, or have iron poisoning ( I kinda doubt it as I take no iron suppliments), I'm at a loss.

Low ferritine can be also associated with hypothyroidism.

Maybe some other iron related tests could be usefull

 

[racerbiker39]

do you know if you have a mutation of any of these two genes?

https://ghr.nlm.nih.gov/gene/SLC11A2#
https://ghr.nlm.nih.gov/gene/TMPRSS6

both can cause iron related anemia...

@patt I have a bunch of TMPRSS6 homozygous mutations.
TMPRSS6 rs2246092 G GG +/+
TMPRSS6 rs855791 A AA +/+ (Pathogenic)
TMPRSS6 rs9619658 T TT +/+

I have been trying to see others have it and match my symptoms? Food intolerances, Anxiety, mood issues etc

 

[pattismith]

A 2017 study on hematochromatosis showed that a high CD4/CD8 ratio is an aggravating factor:

"Our data indicate that homozygosity for the HLA-A*03 allele significantly increases the risk of excessive iron loading in Norwegian p.C282Y homozygous male patients.

In addition, low CD8 + cell number or high CD4 + cell number further increases the risk of excessive iron loading. "

 

[Learner1]

As long as we're talking about iron, it might be worthwhile to note that high iron might exacerbate a case of COVID and urine chelators may be useful.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264936/