One of the findings of the big Stanford/Columbia study was that leptin, in particular, varied depending on how long you have had the disease. First it's too low, later it's too high.
I've had this @#$% disease for 25 years, possibly longer. I never fully recovered from the CMV mono infection I got in 1989, which only got worse as time marched on. And a solid case can be made for having fibro many years before that, possibly even in my teens.
So here I am, 25 years in, and my leptin is acting like someone who recently got sick. Which makes me think that whatever it is that shifts in us for this change to occur, never happened in me.
I am still taking colchicine and Valcyte. My most recent kidney and liver tests were within normal range. I've been taking them for five or six months. I can't say if they are helping me. I had a very good October but November was bad. I think one has to give these drugs a very long time to get any benefit.
I'm going to try harder to resist the temptation to do things when I feel better, and spend my time in bed or on the couch. My cat appreciates it even if no one else does.