Thanks for the post. I guess I was looking at the overall prevalence that nutrahacker has which is around 16% (genotype frequency).
I noticed another gene which may compound the problem, and cause a reduction in choline levels. So maybe it takes a combination:
Folate One-Carbon
Metabolism /
Methylation (FOCM)
rs2236225 MTHFD1 G AA: 2/2 13.0933% Three distinct enzymatic activities
related to folate
Increased requirement for choline Choline
In any case I would still say fatty liver could mirror allot of the symptoms of adrenal fatigue / CFS, even without a genetic way to determine it.
Unfortunately Nutrahacker copies information from various sources without checking whether it is accurate. Please can I encourage you to research further any information you get from Nutrahacker. Some of it is right, some is partly right and some of it is completely wrong.
rs2236225 is snp on the folate pathway. I am heterozygous for that one. It only impacts choline indirectly by having an influence on the conversion of Homocysteine to Methionine, so would only be relevant to choline when PEMT is not working properly. The answer to the MTHFD1 snp surely would be adequate folate for the cycle to run properly rather than adding choline.
Some snps do have an effect on the requirement for dietary choline, but studies say it is neither of those ones listed above.
http://www.ncbi.nlm.nih.gov/pubmed/16816108
http://www.ncbi.nlm.nih.gov/pubmed/19167960?dopt=Abstract
On the other hand in those who are obese (a factor contributing to fatty liver) those snps are shown to be relevant and betaine or choline supplementation is considered a possibility to explore. It may even be that these snps contribute to obesity.
http://www.nature.com/nutd/journal/v2/n10/full/nutd201223a.html
Like Celiac disease where 40% of people carry the genes which predispose to an illness which only around 1% of people get, non-alcoholic fatty liver may require certain predisposing genes as well as exposure to another factor (like, for one example, a high fat diet) in order to get the illness. I would not say someone with these snps has an increased need for choline anymore than I would say the 40% of people carrying celiac predisposing genes need to avoid gluten.
It is still interesting and worth following up, sorry I just have difficulty with Nutrahacker's inaccuracies.