Here's a list of SNPs from 23andMe which have research showing them to be risk factors. Missense mutations are bolded, underlined, and orange.
D919G (A2756G) was particular interesting, as there is a great deal of contradictory information. Much of that comes from cancer research which can a bit problematic due to extra factors coming into play. Most of the research on direct levels of homocysteine says that G is the risky allele. Also, several studies have found that the risk from G is only present, or more pronounced, when combined with other methylation SNPs, most notably G alleles from MTRR missense mutation I22M (A66G).
I'm also doubtful regarding the heartfixer.com explanation that D919G is an upregulation. If it's grabbing up all the available homocysteine, it doesn't make for homocysteine to then be elevated, as is shown in many studies.
T3738 is also a bit of a mystery. I couldn't find much research, but table 3 of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1626421/ indicates it's significant. However it's not clear which allele they're referring to.
rsID.........NAME....RISK...ETC
rs10925235...T3738C..T?
rs12749581...R52Q....A
rs12060264...G275A...A
rs121913582..A410P...C....i5008207
rs121913580..R585X...T....i5008205
rs1770449....T15C....CC
rs1805087....D919G...G....worse with MTRR I22M G alleles
rs121913579..H920D...G....i5008204
rs2275565....G157T...TT
rs1050993....A1361G..AA
D919G (A2756G) was particular interesting, as there is a great deal of contradictory information. Much of that comes from cancer research which can a bit problematic due to extra factors coming into play. Most of the research on direct levels of homocysteine says that G is the risky allele. Also, several studies have found that the risk from G is only present, or more pronounced, when combined with other methylation SNPs, most notably G alleles from MTRR missense mutation I22M (A66G).
I'm also doubtful regarding the heartfixer.com explanation that D919G is an upregulation. If it's grabbing up all the available homocysteine, it doesn't make for homocysteine to then be elevated, as is shown in many studies.
T3738 is also a bit of a mystery. I couldn't find much research, but table 3 of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1626421/ indicates it's significant. However it's not clear which allele they're referring to.
rsID.........NAME....RISK...ETC
rs10925235...T3738C..T?
rs12749581...R52Q....A
rs12060264...G275A...A
rs121913582..A410P...C....i5008207
rs121913580..R585X...T....i5008205
rs1770449....T15C....CC
rs1805087....D919G...G....worse with MTRR I22M G alleles
rs121913579..H920D...G....i5008204
rs2275565....G157T...TT
rs1050993....A1361G..AA