@Hip @nanonug
Just to make some points which may be of interest :
1) I've recently sent to
@Janet Dafoe (Rose49) a confirmation that Machine Learning Algorithms score "Sepsis" as Highly relevant to ME/CFS. "Sepsis" is the second most highly relevant Topic after "Liver Disease".
2) On February 5th 2018 i shared a Video with
@Janet Dafoe (Rose49) where Network Analysis identifies the following areas as being relevant to ME/CFS :
-Liver (Liver Injury, Steatohepatitis, etc)
-Inflammation
-ER Stress and Unfolded Protein Response (UPR)
Here is a snapshot of the same video at approximately 5 minutes, 28 seconds (see JNK, Inflammatory response among the topics chosen by Network Analysis) showing the Inflammation Segment of the Network:
3) Some weeks ago i shared with Janet a 33-page document which explains the "Multiple Pathways Hypothesis" with the latest findings from Machine Learning. Among them is
Catalase.I am pasting the following snapshot from within the document which i believe is relevant to this discussion (Notice LPS, JNK, Nf-Kb pathway). Note that this excerpt was taken from a Book called "Molecular Pathology of Liver Disease" :
EDIT :
@Hip
I believe that the "Bile" mentioned here is also very important :
Finally, if LPS crosses the gut mucosa, it is directed via the portal vein to the liver, where major detoxification processes occur by deacetylation and excretion through the bile. If this disposal process is not sufficient, LPS enters the systemic circulation, where it is handled by numerous transport proteins that clear it back to the liver for further excretion.
-What would happen if for some reason Bile Acid Metabolism is impaired?
-Why do quite a few cases of ME/CFS Patients i know where found to have Total Bile Acids (=Serum TBA) elevated?