In Belgium to see Dr de Meirleir
- Thread starter Valentijn
- Start date
I don't know why he prescribed it, I would like to know more why certain things are prescribed but unfortunately there is no explanation.
How do you know kynuneric acid is elevated? It actually is.
Is there a relation between 5HTP and kynuneric acid?
I posted my results and prescriptions in @dadouv47's thread because there are some similarities:
http://forums.phoenixrising.me/index.php?threads/post-lyme-treatment-with-kdm.44452/#post-728393
Let's see if we can also equally progress with this treatment.
I am planning to start everything step by step, today I start with the 5HTP and then step by step add:
- all other supplements.
- the B12 injections.
- Mesalazine
- Antibiotics
- Samento/Banderol/Cumanda
How do you know kynuneric acid is elevated? It actually is.
Is there a relation between 5HTP and kynuneric acid?
I posted my results and prescriptions in @dadouv47's thread because there are some similarities:
http://forums.phoenixrising.me/index.php?threads/post-lyme-treatment-with-kdm.44452/#post-728393
Let's see if we can also equally progress with this treatment.
I am planning to start everything step by step, today I start with the 5HTP and then step by step add:
- all other supplements.
- the B12 injections.
- Mesalazine
- Antibiotics
- Samento/Banderol/Cumanda
I'm still researching the why and how but simply put, I think KDM prescribes 5HTP because too much tryptophan gets converted into kynurenic acid + quinolinic acid and not enough into serotonin, which then leads to increased oxidative stress and NMDA receptor activation.
@msf also mentioned that kynurenic acid can be a direct result of systemic inflammation.
I have high kynurenic acid too. + low urinary 5-HIAA (low serotonin due to trytophan steal -> kynurenic acid and quinolinic acid?). I suffer from constant anxiety and overstimulation, NMDA antagonists like magnesium can really calm me down, so i believe there's something to this.
https://neuroendoimmune.wordpress.com/2013/10/01/psychoneuroimmunology-where-kynurenic-acid-fits/
@msf also mentioned that kynurenic acid can be a direct result of systemic inflammation.
I have high kynurenic acid too. + low urinary 5-HIAA (low serotonin due to trytophan steal -> kynurenic acid and quinolinic acid?). I suffer from constant anxiety and overstimulation, NMDA antagonists like magnesium can really calm me down, so i believe there's something to this.
https://neuroendoimmune.wordpress.com/2013/10/01/psychoneuroimmunology-where-kynurenic-acid-fits/
@Thinktank - seems that 5HTP is an anti-depressant. Maybe we look so depressed so that's why this item was included in the treatment plan? 
He prescribed it to me to help generate serotonin.
@Valentijn hi! I know this is an old thread but I wanted to see how you are doing since start dr KDMs treatment? I am due over in 4 weeks to get my treatment plan!
I saw he recommended a diet free of simple sugars? What does that mean and does he explain all that?
I saw he recommended a diet free of simple sugars? What does that mean and does he explain all that?
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Sorin,
KDM prescribed 5HTP for our daughter as well. There was another thread in which some members explained why to take it. I think it's something to do with serotonin... but don't know where to find this thread.
What I (I'm taking it because of my bad sleep) know is, it may take some time until it starts working.
KDM prescribed 5HTP for our daughter as well. There was another thread in which some members explained why to take it. I think it's something to do with serotonin... but don't know where to find this thread.
What I (I'm taking it because of my bad sleep) know is, it may take some time until it starts working.
if the goal his to increase serotonin, it's going to take AT LEAST 3 weeks for having a VERY small result from it and probably 2-3 months to have a real effect on the serotonin and keeping a higher level of serotonin during the next months (and probably year if you remain taking it).
If there was any drug helping to increase serotonin so fast, some company would win even more money than they already win by prescribing so many antidepressants.
Regards
David
If there was any drug helping to increase serotonin so fast, some company would win even more money than they already win by prescribing so many antidepressants.
Regards
David
@dadouv47 -- not the case for those who are serotonin-sensitive, which includes many PWME. I had a serotonin-syndrome-like episode after 2 pills of 5-HTP 2 days apart.
-J
-J
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My blood serotonin is a bit low, but pee serotonin is normal, indicating that brain serotonin may be high.
Regardless, that may be why many report more emotional and cognitive symptoms at onset than later. Serotonin receptors (and other receptors) can up- or down-regulate over time to become more or less sensitive.
Regardless, that may be why many report more emotional and cognitive symptoms at onset than later. Serotonin receptors (and other receptors) can up- or down-regulate over time to become more or less sensitive.
Hi, I am new. I have had CFS for 3 years now. I have some of my test results back (see below the abnormal results from RED / KdM) and am trying to get smarter before speaking to the doc next month.
My question is, do others take L-carnitine to address high ammonia levels?
Thanks!
Ammonia in serum – 5.51 (0.28 – 3.03 ratio to normal median)
CD57 – 58 (60 – 360 cells)
Elastase expression – 246 (0-150)
Prostaglandine E2 – 3.87 (0.3 – 2.06 ratio to normal median)
Quinolinic acid – 1.52 (0.75 – 1.16 ratio to normal median)
Soluble CD14 – 3254 (1430 – 2800 ng/ml)
IL-1beta serum – 7 (0-3 pg/ml)
IL-6S – 13 (0-5 pg/ml)
IL-8S – 1416 (0-15 pg/ml)
SeroEBVblotIgG – Positive (past)
SeroEBVblotIgM – Negative
SeroYERSIgA – Negative
SeroYERSIgG – Positive
My question is, do others take L-carnitine to address high ammonia levels?
Thanks!
Ammonia in serum – 5.51 (0.28 – 3.03 ratio to normal median)
CD57 – 58 (60 – 360 cells)
Elastase expression – 246 (0-150)
Prostaglandine E2 – 3.87 (0.3 – 2.06 ratio to normal median)
Quinolinic acid – 1.52 (0.75 – 1.16 ratio to normal median)
Soluble CD14 – 3254 (1430 – 2800 ng/ml)
IL-1beta serum – 7 (0-3 pg/ml)
IL-6S – 13 (0-5 pg/ml)
IL-8S – 1416 (0-15 pg/ml)
SeroEBVblotIgG – Positive (past)
SeroEBVblotIgM – Negative
SeroYERSIgA – Negative
SeroYERSIgG – Positive
Don't know about L-carnitine (not taking it), but I think KDM pays attention very carefully to ammonia. My ammonia went from 5,84 to 1,65 in 3 months of treatment ( not feeling general health's improvements but still significant change). Can't really tell what helped to reduce it so much... =/