Improved on triple anticoagulant therapy, considering adding tenofovir

[Lalique]

After 2+ years of Long Covid which presents with moderate ME/CFS symptoms, I decided to give triple anticoagulant therapy a go.
It took 40 days to see the difference. After 40 days, my ability to look at screens increased manyfold. Pain in the eyes which was major issue almost disappeared. The frequency of crashes went from every 3-5 days to once a week, sometimes once in two weeks. PEM is shirter and less profound. Sadly, my physical exertion intolerance improved little to none.
I have been on this therapy 5 months now and the first gains, hovever consisent are the only gains I have,

I wonder if anyone tried adding antivirals, especially tenofovir to TT or knows of a reason we shouldn't.
I am aware tenofovir is hard on the kidneys and so us aspirin in the long run.

 

[Woodyrob]

Hi what were the 3 chemicals, drugs or compounds you used?
I used Aspirin 75mg x twice daily, Rivaroxaban 10mg once daily, and Nattokinase at night , plus I even took low dose Sildenafil (viagra) approx 15mg 3 x daily, which helps brain fog. But unfortunately no physical gains.
I must say it was late in the experiment on myself that I took Nattokinase. As only a few weeks later my doctor decided to stop the Rivaroxaban, as I hadn’t had been able to increase my walking of more than 50 metres.
I still take Sildenafil, Aspirin and Nattokinase for Brain fog. Ah and caffeine as that actually helps a little too. But unfortunately none are game changers for me

 

[Lalique]

Hi, I took apixaban, clopidogrel and aspirin, as described in:
https://www.researchgate.net/public...ID_symptoms_with_triple_anticoagulant_therapy
I have upped aspirin to 100mg daily because my transfuziologist says these are laughable small antiplatelet doses that'll only result in development of resistance.
I know a lot of people on natto-none of them have tangible results. On the other hand, I know a lady who is on apixaban alone now and manages to keep her significant gains. I know another who went from severe to moderate on TT 10+ years after developing ME. It is not a cure; I have never met a person who went into a full remission on TT and, in theory, it is quite risky, but, without at least 3 monts of apixaban or equivalent (and someone to monitor you on it), you can't know if you are a responder or not.

 

[godlovesatrier]

You might be better with valtrex and looking at some sort of immune modulator for mtor. Low dose Metformin might do it 200 to 500mg extended release. Tenofovir worked in 50% of Dr chia and Dr weird patients however so you might do ok on it. Should take 3 months before you see any effect tho.

I've tested Metformin and had a viral herx on it and felt a lot more energised thereafter. I've also taken low dose Doxycycline for neuro inflammation. (It helps with the screen issue you were having) But triple therapy is what I would like to try next with my Dr.

A more risky treatment might be rapamycin once a week. But that could just make things worse.

 

[Lalique]

I have done 500mg metformin daily before TT, for 4-5 months. It had no impact, good or bad. I have even taken it as a post exposure profilaxis while on TT, but, I think if it worked for me, it would have worked by now.
I am worried about toxicity of any antiviral, valtrex or tenofovir, but, at the same tine, I don't like the idea of attemptimng antiviral monotherapy. I whish I could add something like interferon, even if it was oral intereferon alpha+antiviral+TT.

 

[godlovesatrier]

Hello,

Yes these drugs don't always work. Lots of trial and error. I took Metformin for autoimmune symptoms but it did help my fatigue too.

As for valtrex it's the kidneys you need to be careful with. Because it forms crystals in the urine. So drinking lots of water is vital. Apart from that I'd say it's one of the least toxic. I've been taking it for 3 years now.

Tenofovir is meant to be worse but am not really sure what it would cause. Neutropenia maybe. I suffer from that even without antivirals so that wouldn't be something I'd want to make worse.

On Facebook long covid patients seem to take cyloferon. You could look that up on Facebook LC groups.

 

[Lalique]

Thanks! I didn't consider cycloferon: I'll look it up.

 

[Treeman]

Hi, I underwent triple therapy anti coagulants for 2-3 months before I stopped (aspirin 75mg, apixiban 5mg clopidogrel 35mg daily) I noticed my muscle pain ceased bit i didn't have a noticeable increase in energy. After a couple or so months the muscle pain is back.

I stopped because I wanted to try Tavin-em (tenoforvir disoproxil 300mg & emtricitabine 200mg) and didn't want to over tax my kidneys etc. I have settled on just half a tablet a day due to the side effects of a full tablet ( most noticeable was an increase in fatigue). I'm hoping to slowly increase the dose eventually. I noticed I have slightly more energy.

Hope this is helpful.

 

[Lalique]

Hi, I underwent triple therapy anti coagulants for 2-3 months before I stopped (aspirin 75mg, apixiban 5mg clopidogrel 35mg daily) I noticed my muscle pain ceased bit i didn't have a noticeable increase in energy. After a couple or so months the muscle pain is back.

I stopped because I wanted to try Tavin-em (tenoforvir disoproxil 300mg & emtricitabine 200mg) and didn't want to over tax my kidneys etc. I have settled on just half a tablet a day due to the side effects of a full tablet ( most noticeable was an increase in fatigue). I'm hoping to slowly increase the dose eventually. I noticed I have slightly more energy.

Hope this is helpful.

Thank you! We are thinking along the same lines; I am also wortied about overtaxing the kidneys.
I hope Tavin works for you

 

[andyguitar]

After 2+ years of Long Covid which presents with moderate ME/CFS symptoms, I decided to give triple anticoagulant therapy a go.
It took 40 days to see the difference. After 40 days, my ability to look at screens increased manyfold. Pain in the eyes which was major issue almost disappeared.

Sounds like a good result , did you get any side effects?

 

[Wayne]

Pain in the eyes which was major issue almost disappeared.

Hi @Lalique -- Congratulations on your eye improvements. If you're interested in more possibilities on improving eye health, you may want to check out the following posts. The first is on DMSO and Magnesium Oil. The second one is on hyaluronic acid.

Daily episodes of blurry vision and pain around eyes​

And this post on hyaluronic acid the same thread.

 

[Lalique]

Sounds like a good result , did you get any side effects?

I had one terribly heavy period, but, other than that, just some slight bruising and heartburn