alpha acids reduce the inflammatory cytokine IL-6 (see
this study provided by Richard), and IL-6 seems to cause reduced concentration and brain fog symptoms: IL-6 causes fatigue, reduce ability to concentrate,
ᐞ difficulties with memory and learning,
ᐞ and cognitive decline
ᐞᐞ. In short, IL-6 seems to be a sort of "essence of brain fog" cytokine. And studies have shown IL-6 to be elevated in ME/CFS.
ᐞ
The cocktail of IL-6 inhibitors I took before socializing were the following:
IL-6 inhibitor Protocol:
Luteolin 100 mg
Idebenone 200 mg
Q10 200 mg
PABA 500 mg
Horny goat weed (Epimedium) 900 mg
Curcumin 900 mg
Vitamin D 10,000 iu
Vitamin E 400 mg
Pregnenolone 25 mg
Vitamin K 100 mg
Vinpocetine 30 mg
Genistein 56 mg
Daidzein 37 mg
Amla 2000 mg
Niacinamide 500 mg
Some study references for above IL-6 inhibitors:
Four
macrolides (roxithromycin, erythromycin, clarithromycin and azithromycin) inhibited IL-1β, TNF-α, IL-6 LPS-stimulated J774 macrophages.
1 (
full text). NOTE:
Roxithromycin is the only macrolide antibiotic that crosses the blood brain barrier.
Macrolide antibiotics (like azithromycin and erythromycin) inhibit IL-6
1
Amoxicillin significant decreased IL-6 plasma levels by the 7th day of therapy.
1
Vitamin C and
vitamin E inhibit
muscle-derived IL-6.
1
Blueberries reduce TNF-α and IL-6 in mouse macrophages
1
Patchouli alcohol (from patchouli essential oil) inhibits IL-1β, TNF-α, IL-6 in mouse macrophages (RAW 264.7 cells)
1
Genistein inhibited LPS-induced IL-1beta, IL-6, and TNF-alpha expression in macrophages.
1
Vinpocetine inhibited the production of inflammatory factors such as IL-1β, IL-6 and TNF-α in BV-2 microglia.
1
Sulforaphane attenuates the LPS-induced increase of IL-1beta, IL-6, and TNF-alpha expression in microglia
1 Sulforaphane reduces TNF-α-induced IL-6 synoviocytes
1
Vitamin D inhibits LPS-induced IL-6 and TNF-α production in macrophages.
1
Cyclosporin A decreases human macrophage interleukin-6 synthesis.
1
Luteolin reduces IL-6 production in microglia.
Luteolin: 90% drop in IL-6 production.
1 Pretreatment of primary microglia with 10 and 25 μM luteolin reduced LPS-induced IL-6 production by 40% and 90%, respectively. When luteolin was increased to 50 μM, IL-6 secretion by LPS-stimulated microglia was completely blocked. If we take the bioavailability of luteolin to be 5%, then the dosage to achieve a 25 μM concentration is 25 x 286.24 / (55 x 250) = 520 mg of luteolin. NOTE: the lutein bioavailability when given as Chrysanthemum morifolium extract is 55.4%, but for pure lutein is may be much lower.
1
Alpha acids and
iso-alpha acids in
hops (found in beer) block the TNF-alpha induced production of IL-6.
1
Polyphenols in non-alcoholic beer reduce IL-6
1
Calendula officinalis (marigold) inhibits IL-1beta, IL-6, TNF-alpha and IFN-gamma.
1
Magnolia officinalis (Magnolia) Obovatol (from Magnolia) attenuates microglia-mediated neuroinflammation.
1
Niacinamide 1
Pyrroloquinoline quinone (PQQ) reduces IL-6
1
