I might be able to add a little insight to this.
I had a background of being outdoorsy with hunting and playing in the woods as a kid. Yes there were two separate times I got ticks on me. No rash, no symptoms, nothing... It was about 10 years later I got sick with what doctors are now calling CFS/POTS.
When I first became ill, about a year into my illness we thought, "What about lyme?" I went to an infectious disease doctor, he ran his western blot and ELISA. All Negative. Then I went to a 'LLMD' and she ran a Bowen test. I was positive. Well it turns out all Bowen test comes back positive. So I go to another 'LLMD', he runs Igenex. It comes back positive'ish'. So he does oral antibiotics along with heparin on me for a year. I don't get any better.
I go to a lyme disease treatment clinic for almost 2 years where I get IV antibiotics, oral antibiotics, meyers cocktails, heparin, bicillin shots, and tons of supplements. They also used Igenex. There was always about 30 patients there receiving treatment, and they would come and go. Many never got better and just ran out of money. Many of these patient's family and friends would use the Igenex test on themselves and they were positive even though not sick...
My mom ran the test on herself and she was positive. After I decided to leave and seek other doctors, I found out that clinic got shutdown for tax evasion, false diagnosis lawsuits, insurance fraud, faulty accounting practices, and the list goes on. The doctor lost her license and was put under house arrest, her husband I believe served time in jail while also owning a lot of taxes.
I would say I am pretty confident I don't have lyme. One thing to point out, I think everyone needs to get away from the word 'lyme'. They need to start calling infections for what they are. Borrelia, bartonella, babesia, RMSF, ect.