i have wasted 100s and 100s of dollars on supplements, most of them do absolutely nothing or make me worse, herbs in particular seems to be a complete waste of money for me, though i've heard others raving about them. I guess it takes a lot of money and trial and error to find the right ones, and i just cant be bothered any more!
B vits make me worse, (have tried all types) though b6 has possibly been helpful it's hard to say. Andrographis and lemon balm completely wiped me out for two weeks after just one dose! and rhodeola also makes me sleepy. I have tried ginseng which gives me a little perk up but then super sleepy, so thats pointless too. Curcumin makes me brain fogged. Liquorice gave me awful migraines.
NT Factor - which i do believe could be beneficial for many, made me highly irritable and sound sensitive, so frustrating!
My main thought on this is everyone is so different it's impossible to suggest something that will guarantee to work for you though there does seem to be a few supps that seems to have a wider range of effectiveness. I have put them down below, they seem to have some small amount of benefit to me, and they also seem to be effective for more people.
Magnesium keeps my restless legs at bay, but can only take mag malate, as the other forms either do nothing or make me incredibly sleepy. Magnesium can also be helpful with migraine but i'm not sure it helps mine.
D-ribose gave me like a 1-5% improvement for maybe an hour - not worth the money or effort.
PQQ with coQ10 did make me feel a little better for a couple of weeks but of course i over did it and crashed, so you have to be careful with that, but i am thinking of trying it again.
NAC seemed to really help with my toxic feeling, head pressure and spine pain but now it doesn't seem to do much, though it seems to have actually permanently improved my spine pain so that is pretty cool. I do take it every so often to see if it will help further, but I can't tell, maybe it's done all it can.
I take vitamin D and K, the K seems to give me really heavy periods, but i do think the D stops me getting hand cramps, and in general it seems good to take D.
I also take C for immunity but again, haven't noticed much.
I have tried several different probiotics, and they made me have panic attacks. I tried Colostrum which i think did help with gut issues, but can only take for a few days or i'll start getting panic attacks. For gut issues i feel prebiotics is a safer approach, and have had some luck with inulin powder, and generally eating a diet high in prebiotic foods, resistant starch (cooked then cooled rice or potatoes) has made a more impactful improvement in my gut health over supps, but i don't have IBS i just get migraines that i believe are related to gut biome/flora imbalances.
Aminio Acids have been somewhat helpful and you'll hear others rave about them too. Phenylalanine/tyrosine seems to help me with migraines and irritablity, and i sometimes use it along side ritalin to reduce side effects.
Taurine has helped a little with anxiety as well as theanine, so i use them for when anxiety stops me sleeping. Taurine also seems to make a small improvement in my tinnitus.
So hopefully there's some idea of what to look into.