seroquel, did not work. phenergan either. diphenhydramine, built up tolerance does not touch it, temazapam, nope, baclofen, have it - only helps for spasms not sleep, lyrica, nope. Will try researching the others and very thankful for the suggestions. I do believe I am a tough case with sleep issues. Thanks
heapsreal
I sort of get what your going through, quick tolerance to things or just plain dont work. Im in a constant battle of rotation, trial and error to get sleep.
Something to consider and look into further is cortisol cycle and rhthym, high in morning and low at night, trying to manipulate that the best way u can with supps and adrenal hormones, cortisol blockers etc this has helped improve my sleep quality better and sleep meds arent hit and miss as much.
But another thing i have been reading about for fixing sleep rhthyms is a drug called cycloset which is a low dose dopamine agonist used in type 2 diabetes. It is suppose to help reset our body clock through regulating the hypothalamus and helps the body to increase its own natural morning cortisol production etc in a more normal cyclic fashion. Its taken when one wakes up in the morning. This use and theory of cycloset is being used by dr jack kruse with success, so maybe google some of this stuff and see if it helps. Some of dr kruses stuff is abit out there but this cycloset theory makes sense as well as his adrenal fatigue info which is abit different to other common info out there.
Cycloset and FBG update, oh my!
This is the OSA battling the cycloset......I'd tell you to give it some time to work itself through. If sleep is still an issue You may want to increase DHEA to help foster sleep. The cycloset can cause an upset stomach because of how it dramatically alters the gut flora because of the acute changes in cortisol and dopamine in the brain and the gut.
Remember the cycloset is made for increasing AM cortisol......Works awesome and is a great way to stop taking hydrocortisone in LR states or in Adrenal fatigue. Lots of educational consultants are hearing about how I might consider to use it now.
Cortisol is a stress hormone that is linked with dopamine production in the brain. Levels of cortisol in the bloodstream are highest during rising in the AM, which in turn leads to higher dopamine levels during daytime. Dopamine, a neurotransmitter, is directly responsible for a number of important functions in the brain, including attention and learning when we rise.
Recent studies have suggested that the circadian neuroendocrine rhythm mediated by dopamine and serotonin plays a large role in insulin sensitivity. In people without diabetes, the postmeal state causes a decline in endogenous glucose production due to suppression of glucagon and inhibition of lipolysis. In individuals with T2D, a drop in dopamine levels is thought to lead to an inadequate hypothalamus response, resulting in elevated levels of blood glucose, free fatty acids (FFA), and triglycerides (TG), which contribute to insulin resistance, visceral adiposity, and beta-cell dysfunction. Clinical studies suggest that bromocriptine-QR administered in the morning (within 2 hours of waking) mimics the normal peak of dopamine in the central nervous system, consequently thought to reset this circadian rhythm. The main target organ of bromocriptine is the brain.
However, subsequent effects have been observed in adipose tissue (due to decreased levels of glucose, FFAs, and TGs) and the liver (reduced hepatic gluconeogenesis due to reduced cortisol levels in response to dopamine). Higher brain dopamine levels will reduce the cortisol spikes seen in Leptin resistant states like T2D or IR.
http://jackkruse.com/forum/showthread.php?2927-Cycloset-and-FBG-update-oh-my!
