Hip
Senior Member
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What we need here is @mariovitali's data mining software, which may help uncover the biochemical pathway(s) behind this PEM-reducing effect of ibuprofen.
This kind of situation comes up time and time again on this forum: someone notices that a drug or supplement improves one or more of their symptoms, and they want to know why; they want to know the biochemical pathway(s) by which the medication is having its effect.
If you can make a good guess at the pathway, you can then try other drugs or supplements that act on the same pathway, which might provide further benefits.
It would be great if we had a pharmacodynamics search engine where we could type in a medication (like ibuprofen), and type in an ME/CFS symptom or condition (like PEM) that was improved by that medication, and then search engine would return several suggested biochemical pathways by which that medication might be exerting its effect.
I don't understand it fully, but apparently mariovitali's software does something along the lines of identifying these biochemical connections.
This kind of situation comes up time and time again on this forum: someone notices that a drug or supplement improves one or more of their symptoms, and they want to know why; they want to know the biochemical pathway(s) by which the medication is having its effect.
If you can make a good guess at the pathway, you can then try other drugs or supplements that act on the same pathway, which might provide further benefits.
It would be great if we had a pharmacodynamics search engine where we could type in a medication (like ibuprofen), and type in an ME/CFS symptom or condition (like PEM) that was improved by that medication, and then search engine would return several suggested biochemical pathways by which that medication might be exerting its effect.
I don't understand it fully, but apparently mariovitali's software does something along the lines of identifying these biochemical connections.
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