Treeman
Senior Member
- Messages
- 903
- Location
- York, England
HI, I thought I would share my findings of eliminating my IBS-C.
I have the impression that my ME CFS could be caused by continued inflammation, whether that's because of persistent uncontrolled antigen activity or immune dysfunctional, I don't know.
I took the JAK inhibitor Tofacitinib at a daily dose of 5mg and after 3 days I noted my IBS had completely stopped after 30 years. I was able to eat wheat and other products again after not being able to for years and I also noticed some of my food intolerances had improved. Unfortunately, after 6 weeks I decided to stop the treatment as I noticed I had developed a chronic respiratory infection and thought it was due to the medication. Four days after stopping the Tofacitinib my IBS returned. A few weeks after stopping the treatment the respiratory infection ceased.
I tried to make sense of what had happened with some of the things I know about my health. JAK inhibitors are an immune suppresser, but this research Here informs that they "work by attenuating multiple cytokine signalling pathways to mediate dysregulated immune responses involved in the pathogenesis of IBD"
Here I then noted this research that informs "Resected mesenteric lymph node [MLN] cells from 19 patients [9 CD, 10 UC] were analysed". At this point I remembered that a CT imaging I had previously undertaken had commented that I had, "shotty mesenteric lymph nodes up to 1cm"
The mesentery is a fold of membrane that attaches the intestine to the wall around the stomach area and holds it in place. Mesenteric lymphadenitis is swelling of the lymph nodes in the mesentery.
Here It informs that, Mesenteric lymphadenitis, a swelling of lymph nodes in the mesentery (the tissue connecting the intestines to the abdominal wall), can be a cause of abdominal pain and discomfort, potentially mimicking symptoms of Irritable Bowel Syndrome (IBS)
So, I'm left considering that the swollen lymph nodes I have are the cause of my IBS. I have had in addition to the CT scan a colonoscopy and they both inform that there is no abnormality in the colon.
During the Tofacitinib treatment my fatigue did not improve. I share this with the hope it helps someone.
I have the impression that my ME CFS could be caused by continued inflammation, whether that's because of persistent uncontrolled antigen activity or immune dysfunctional, I don't know.
I took the JAK inhibitor Tofacitinib at a daily dose of 5mg and after 3 days I noted my IBS had completely stopped after 30 years. I was able to eat wheat and other products again after not being able to for years and I also noticed some of my food intolerances had improved. Unfortunately, after 6 weeks I decided to stop the treatment as I noticed I had developed a chronic respiratory infection and thought it was due to the medication. Four days after stopping the Tofacitinib my IBS returned. A few weeks after stopping the treatment the respiratory infection ceased.
I tried to make sense of what had happened with some of the things I know about my health. JAK inhibitors are an immune suppresser, but this research Here informs that they "work by attenuating multiple cytokine signalling pathways to mediate dysregulated immune responses involved in the pathogenesis of IBD"
Here I then noted this research that informs "Resected mesenteric lymph node [MLN] cells from 19 patients [9 CD, 10 UC] were analysed". At this point I remembered that a CT imaging I had previously undertaken had commented that I had, "shotty mesenteric lymph nodes up to 1cm"
The mesentery is a fold of membrane that attaches the intestine to the wall around the stomach area and holds it in place. Mesenteric lymphadenitis is swelling of the lymph nodes in the mesentery.
Here It informs that, Mesenteric lymphadenitis, a swelling of lymph nodes in the mesentery (the tissue connecting the intestines to the abdominal wall), can be a cause of abdominal pain and discomfort, potentially mimicking symptoms of Irritable Bowel Syndrome (IBS)
So, I'm left considering that the swollen lymph nodes I have are the cause of my IBS. I have had in addition to the CT scan a colonoscopy and they both inform that there is no abnormality in the colon.
During the Tofacitinib treatment my fatigue did not improve. I share this with the hope it helps someone.