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http://iacfsme.org/Conferences/2016-Fort-Lauderdale/Agenda/Professional-Agenda.aspx
October 27, 2016. IACFS/ME Conference Keynote Presentation
New ME/CFS Developments at the National Institutes of Health
Dr. Whittemore received her Ph.D. in anatomy from the University of Minnesota, followed by post-doctoral work at the University of California, Irvine, and a Fogarty Fellowship at the Karolinska Institute in Stockholm, Sweden. She was on the faculty of the University of Miami School of Medicine in The Miami Project to Cure Paralysis prior to working with several non-profit organizations including the Tuberous Sclerosis Alliance, Genetic Alliance, Citizens United for Research in Epilepsy (CURE), and the National Coalition for Health Professional Education in Genetics (NCHPEG). She also served a four-year term on the National Advisory Neurological Disorders and Stroke Council.
Dr. Whittemore has been a strong voice for increasing the research commitment for ME/CFS at the NIH. This includes launching a research protocol at the NIH Clinical Center to intensively study individuals with ME/CFS and re-invigorating the efforts of the Trans-NIH ME/CFS Research Working Group. The working group, co-chaired by Dr. Whittemore, consists of representatives from 23 NIH institutes that help to support extramural ME/CFS research. Dr. Vicky Whittemore is also the NIH representative to the U.S. Department of Health and Human Services' Chronic Fatigue Syndrome Advisory Committee.
PLENARY SPEAKER: Dr. Øystein Fluge, Chief Physician, Department of Oncology, Haukeland University Hospital, University of Bergen, Norway
Dr. Fluge is Chief Physician in the Department of Oncology at Haukeland University Hospital, University of Bergen, Norway. He received his medical degree in 1988 from the University of Bergen and has specialized in oncology since 2004. He has conducted research at the Surgical Institute and Department of Molecular Biology, University of Bergen and has been funded as a Research Fellow by the Norwegian Cancer Society.
In 2004, Dr. Fluge and his colleague, Dr. Olav Mella, a neurologist at the same institution, noticed that a patient’s ME/CFS symptoms improved substantially while undergoing chemotherapy treatment for a concurrent diagnosis of lymphoma. This was followed by a pilot study in 2009 with positive results. In 2011, Dr. Fluge, Dr. Mella, and their colleagues published a randomized double-blind placebo-controlled trial of rituximab in 30 ME/CFS patients demonstrating that two-thirds of the intervention group experienced moderate to major improvements in their ME/CFS symptoms. For a medical condition with no disease-modifying treatments, this was a ground-breaking study. Currently, they are in the midst of attempting to replicate their results in a larger Phase III multi-center study in Norway.
12th International IACFS/ME Biennial Clinical and Research Conference
Emerging Science and Clinical Care
Thursday, October 27th
9:30 am – 12:30 pm
Professional workshops (run concurrently; attendees select one only)
Review of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Fibromyalgia and Multiple Chemical Sensitivities/Environmental Sensitivities: Office Assessment and Management
Alison Bested, M.D., F.R.C.P.C.
Clinical associate professor, Department of Medicine, University of British Columbia
Acute and Chronic Enteroviral Infection
John Chia, M.D.
UCLA School of Medicine
How Cardiopulmonary Exercise Testing Informs Pathology and Treatment
Staci Stevens, M.A.
Founder, WorkWell Foundation
1:30 pm – 4:30 pm
Professional workshops (run concurrently; attendees select one only)
Behavioral Assessment and Treatment of ME/CFS and Fibromyalgia
Fred Friedberg, Ph.D.
President, IACFS/ME
Research Associate Professor, Stony Brook University
Founder and Editor, Fatigue: Biomedicine, Health and Behavior
Diagnosing and Treating Orthostatic Intolerance
Peter Rowe, M.D.
Johns Hopkins University School of Medicine
NIH Grant Writing Workshop
Vicky Whittemore, Ph.D.
Program Director, Channels, Synapses and Circuits
National Institute of Neurological Disorders and Stroke
General Session Agenda-Friday, October 28th
8:00 am – 8:15 am
Welcome and Introduction
Fred Friedberg, Ph.D.
President, IACFS/ME
Research Associate Professor, Stony Brook University
Founder and Editor, Fatigue: Biomedicine, Health and Behavior
8:15 am – 9:00 am (last 15 min. are Q and A)
Plenary Session
B-lymphocyte depletion and disease mechanisms in ME/CFS
Oystein Fluge, M.D.
Chief Physician, Department of Oncology,
Haukeland University Hospital, University of Bergen, Norway
Paper Sessions following short paper presentations each 12 minutes in length, presenters will field questions written on cards by the audience and given to the chair as time permits.
9:00 am – 10:15 am
Session 1: The Latest Research in Immunology and the Microbiome
Session Chair: Sonya Marshall-Gradisnik, Ph.D.
Professor of Immunology, Griffith University, Australia
Exercise testing highlights differences in cytokine profile and network between patients with chronic fatigue syndrome and healthy sedentary participants
Francois Haddad, M.D., Director, Biomarker and Phenotypic Core Laboratory, Stanford Cardiovascular Institute
A panel of biomarkers accurately identifies CFS/ME patients and contributes to the understanding of the pathophysiology of the disorder
Kenny L. De Meirleir, M.D., Nevada Center for Biomedical Research at University of Nevada
A profile of circulating cytokines is associated with disease severity in chronic fatigue syndrome patients
Jose G. Montoya, M.D., Stanford University School of Medicine
Alterations in the enteric bacterial and viral microbiome in ME/CFS
Ludovic Giloteaux, Ph.D., Department of Molecular Biology and Genetics, Department of Microbiology, Cornell University
10:15am – 10:45 am
Break/Visit Exhibits
10:45 am – 12:15 pm
Session 2: Treatment Studies and Clinical Practice
Chair: Daniel Peterson, M.D.
Griffith University, Gold Coast, Australia
Owner, Sierra Internal Medicine, Incline Village, Nevada
Reflections on the rituximab trials
Olav Mella, M.D., Department director/professor, Haukeland University Hospital, Oslo, Norway
Synergy Trial for CFS – a phase 2 study of low-dose methylphenidate plus mitochondrial support
Lucinda Bateman, M.D., Bateman Horne Center of Excellence
N-Acetylcysteine alleviates cortical glutathione deficit and improves symptoms in CFS:
An in vivo validation study using proton magnetic resonance spectroscopy
Dikoma Shungu, Ph.D., Departments of Radiology, Neurology and Neuroscience, Weill Cornell Medicine
A re-examination of the cognitive behavioral theory of CFS
Madison Sunnquist, DePaul University
Potential for an immunosignature assay to aid in classification and prediction of rituximab response in ME/CFS
David Patrick, M.D., FRCPC, MHSc, University of British Columbia School of Population and Public Health
12:15 pm – 1:45 pm
Lunch Break/Visit Exhibitors
Special Lunch Session: ME/CFS studies at the Centers for Disease Control and Prevention
Multi-site Clinic Assessment of ME/CFS (MCAM)
Chair: Elizabeth R. Unger, M.D., Ph.D.
Chief, Chronic Viral Diseases Branch
Centers for Disease Control and Prevention (CDC)
Study design of the multi-site clinic assessment of ME/CFS (MCAM)
Elizabeth R. Unger, M.D., Ph.D.
Jin-Mann S. Lin, Ph.D., Senior statistician/epidemiologist, US Centers for Disease Control and Prevention
Description of the Multi-site Clinic Assessment of ME/CFS (MCAM) Study
Mangalathu Rajeevan, Ph.D., Research Microbiologist, US Centers for Disease Control and Prevention
Data on cognitive function from Multi-Site Clinical Assessment of Myalgic Encephomyelitis/Chronic Fatigue Syndrome (MCAM) – Preliminary Analysis
Gudrun Lange, Ph.D., Consulting Clinical Neuropsychologist, Mount Sinai Beth Israel Pain and Fatigue Study Center.
Exercise testing data from the Multi-Site Clinic Assessment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (MCAM) Study
Dane Cook, Ph.D., Professor ofKinesiology, University of Wisconsin-Madison
Salivary test data from the Multi-site Clinic Assessment of Myalgic Encephomyelitis/Chronic Fatigue Syndrome (ME/CFS) (MCAM) Study
Jin-Mann S. Lin, Ph.D., Senior statistician/epidemiologist, US Centers for Disease Control and Prevention
Pilot study evaluating impact of sample processing and assay format on measured natural killer cell function
Troy Querec, Ph.D., Associate Service Fellow, Associate Service Fellow
1:45 pm – 2:45 pm
Session 3: Gulf War Illness
Session Co-chairs:
Kristy Lidie, Ph.D., US Department of Defense
Victor Kalisinsky, Ph.D., US Department of Veterans Affairs
Gulf War Illness Program Officers
Gulf war illness and chronic fatigue syndrome: lessons learned
Presenter: Lea Steele, Ph.D., Research professor, Baylor University Institute of Biomedical Studies
Brain Immune Interactions in Gulf War Illness: Cytokines and Cognition in US Military Veterans
Kimberly Sullivan, Ph.D., Boston University Medical Campus
Genomic approach to find mechanisms of Gulf War Illness pathobiology
Lubov Nathanson, Ph.D., Institute for Neuro Immune Medicine, Nova Southeastern University
Using gene expression signatures to identify novel treatment strategies in Gulf War Illness
Travis Craddock, Ph.D., Department of Psychology & Neuroscience, Nova Southeastern University
2:45 pm – 3:15pm
Break/Visit Exhibits
3:15 pm – 5:15 pm
Session 4: Diagnosing CFS/ME; Difficult Clinical Cases: Focus on Fatigue and Pain
Session Chair: Nancy Klimas, M.D.
Immediate Past President, IACFS/ME
Professor of Medicine & Director, Nova Southeastern University
Director, Miami VAMC Gulf War Illness & ME/CFS Research Program
Panel:
Lucinda Bateman, M.D., Bateman Horne Center of Excellence, Utah
John Chia, M.D., UCLA School of Medicine
Charles Lapp, M.D., Hunter-Hopkins Center, North Carolina
Dan Peterson, M.D., Sierra Internal Medicine, Incline Village, Nevada
Katherine Rowe, M.D., Royal Children's Hospital , Australia
Peter Rowe, M.D., Johns Hopkins University School of Medicine
5:15 pm – 6:00 pm
Visit Poster Presentations/Exhibits
Evening Session
6:30 pm – 8:30 pm
Common Data Elements (CDEs) for Standardized Testing and Clinical Studies
Chair: Vicky Whittemore, Ph.D.
Program Director, Channels, Synapses and Circuits
National Institute of Neurological Disorders and Stroke
The National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health and the Center for Disease Control and Prevention (CDC) will partner to develop common data elements (CDEs) for standardized testing and common data elements to be recorded in clinical studies/trials of individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The development of CDEs for ME/CFS will facilitate the comparison of results across studies and help to standardize analysis. The session will be led by NINDS and CDC Program Staff to discuss the timeline and process for developing the CDEs and to obtain feedback and input from ME/CFS stakeholders.
General Session Agenda-Saturday, October 29th
8:00 am – 9:00 am
Session 5: CFS, SEID, ME Case Definitions: Clinical vs. Research Criteria
Presenter: Leonard Jason, Ph.D.
Professor, DePaul University, Director of the Center for Community Research
Discussants:
Lucinda Bateman, M.D.
Chief Medical Officer
Bateman Horne Center of Excellence
Salt Lake City, Utah
Jon Kaiser, M.D.
IACFS/ME Board Member
University of California, San Francisco
9:00 am – 10:00 am
Session 6: Symptom Provocation Studies I
Chair: Staci Stevens, M.A.
Founder, WorkWell Foundation
Cardiopulmonary exercise testing demonstrates post-exertional chronotropic incompetence
Mark Van Ness, Department of Health, Exercise, and Sport Science, University of the Pacific
Post-exertional malaise: multiple and unexpected symptoms, sometimes delayed, often prolonged
Lily Chu, M.D., Stanford University School of Medicine
Cognitive function in adolescents with chronic fatigue syndrome/myalgic encephalomyelitis:
A novel paradigm
Sarah Knight, Ph.D., Murdoch Children’s Research Institute, Australia
10:00 am – 10:30 am
Break/Visit Exhibits
10:30 am – 12:00 pm
Session 7: Public Health Research
Chair: Steve Krafchick, MPH, JD
IACFS/ME Board Member
Estimating rates of pediatric chronic fatigue syndrome and myalgic encephalomyelitis in a community-based sample
Leonard A. Jason, Ph.D., DePaul University
Two year follow-up of impaired range of motion in adolescent chronic fatigue syndrome
Peter C. Rowe, M.D., Johns Hopkins University School of Medicine
Allergic disorder phenotypes in ME/CFS and patterns of medical comorbidity and clinical dysfunction
Susan Levine, M.D., Cornell Medical Center, New York City
Exploring the role of sex hormones in driving symptom severity in ME/CFS
Gordon Broderick, Ph.D., Department of Medicine, University of Alberta
Nurses’ acute fatigue predicts sickness absence in the workplace: a 1-year retrospective cohort study
Knar Sagherian, RN, MSN, University of Maryland School of Nursing
Examining the accuracy of a physical diagnostic technique for chronic fatigue syndrome/myalgic encephalomyelitis: a blind controlled study
Ray Perrin, DO, Ph.D., Honorary Senior Lecturer: Allied Health Professions Research Unit, University of Central Lancashire, UK
12:00 pm – 1:30 pm
Lunch Break/Visit Exhibits
Lunch Panel
Special Interest Groups: International Research Networks
David Patrick, Ph.D., Moderator
Professor and Director
School of Population and Public Health
University of British Columbia, Canada
European network on myalgic encephalomyelitis/chronic fatigue syndrome (EUROMENE)
Eliana Lacerda, M.D., Ph.D., Assistant Professor, London School of Hygiene & Tropical Medicine
The case for stratification in ME/CFS: Experience from the UK ME/CFS Biobank
Luis Nacul, M.D., Ph.D.
London School of Hygiene & Tropical Medicine
1:30 pm – 2:30 pm
Session 8: Research on Autonomic Functioning and Comorbidities
Chair: Peter Rowe, M.D., Johns Hopkins University School of Medicine
Postural tachycardia in chronic fatigue syndrome induced by exercise
Madison Keefe, B.S., Georgetown University
Distribution of dolorimetry in CFS, FM, GWI and control women
Amber Surian, M.S., Department of Medicine, Georgetown University
Truncal ataxia is an unrecognized cause of orthostatic intolerance in patients with myalgic encephalomyelitis
Kunihisa Miwa, M.D.
Miwa Naika Clinic, Japan
2:30 pm – 3:30 pm
Session 9: Advances in Brain Research and Neurological Studies
Chair: Anthony L. Komaroff, M.D., Professor of Medicine, Harvard Medical School (retired)
Assessment of neurobiological dysfunction in chronic fatigue syndrome
Ben Natelson, M.D.
Pain & Fatigue Study Center, Mount Sinai Beth Israel
Disrupted functional connectivity in Gulf War illness (GWI)
James N. Baraniuk, M.D., Department of Medicine, Georgetown University
Functional neural consequences of post-exertion malaise in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
Dane B. Cook, Ph.D., University of Wisconsin-Madison
3:30 pm – 4:00 pm
Break/Visit Exhibits
4:00 pm – 5:00 pm
Visit Poster Presentations/Exhibits
5:00 pm – 6:00 pm
IACFS/ME Membership Business Meeting
6:00 pm – 7:00 pm
IACFS/ME Social/Cocktails Hour
7:00 pm – 8:00 pm
IACFS/ME Banquet Dinner
8:00 pm – 9:00 pm
Awards Presentation
General Session Agenda-Sunday, October 30th
8:00 am – 9:15 am
Session 10: Symptom Provocation Studies II
Chair: Betsy Keller, Ph.D.
Department of Exercise and Sport Sciences, Ithaca College
Blood lactate increases more rapidly after a previous exercise challenge in patients with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) than in healthy subjects
Katarina Lien, M.D., Ph.D., University of Oslo
Subsets of ME/CFS patient responses to a 2-day CPET
Betsy Keller, Ph.D., Department of Exercise and Sport Sciences, Ithaca College
Neuromuscular Strain Increases Symptom Intensity in Chronic Fatigue Syndrome
Peter Rowe, M.D, Johns Hopkins University School of Medicine
Polar Metabolites Distinguish ME/CFS Patients and Controls
Maureen Hanson, Ph.D., Department of Molecular Biology and Genetics, Cornell University
9:15 am – 10:30 am
Session 11: Genetics Research
Chair: Jose Montoya, M.D.
Professor of Medicine, Stanford University Medical Center
Single nucleotide polymorphisms in myalgic encephalomyelitis: possible genetic factors influencing pathophysiology
Benjamin Eike, B.A., Nova Southeastern University, College of Osteopathic Medicine
Using gene expression modules to identify gender specific treatments in myalgic encephalomyelitis/chronic fatigue syndrome
Mary G. Jeffery, Institute for Neuro-Immune Medicine, Nova Southeastern University
Epigenetic modifications and glucocorticoid sensitivity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
Wilfred de Vega, Ph.D. Can.
University of Toronto
ME/CFS miRNA analysis, mRNA in-situ hybridization and STAT1 localization upon stress trigger
Paula A. F. Waziry, Ph.D., Institute of Neuro Immune Medicine, Nova Southeastern University
Genomics of chronic fatigue syndrome reveals systemic inflammatory response
Jose G. Montoya. M.D., Stanford University School of Medicine
10:30 am – 10:45 am
Break
10:45 am – 12:15 pm
Session 12: Panel Discussion
“Nothing about us without us:” How community-engaged research can accelerate progress in the field of ME/CFS
Moderator: Lily Chu, M.D., MSHS, Co-Vice President, IACFS/ME; Collaborator, Stanford ME/CFS Initiative
Speaker: William Elwood, Ph.D., Expert, community-engaged research, US National Institutes of Health (NIH) Member, Trans-NIH Working Group for ME/CFS
Panelists
Jin-Mann Lin, Ph.D., Senior statistician/epidemiologist, US Centers for Disease Control and Prevention
Leonard Jason, Ph.D., Professor of community psychology, DePaul University (Chicago, Illinois)
Sonya Chowdhury, Chief Executive, Action for M.E.; Member, United Kingdom ME/CFS Research Collaborative
Jennifer Spotila, J.D., FDA Patient Representative; former chairman, Solve ME/CFS Initiative Board of Directors
12:15 pm – 1:15 pm
Lunch/Visit Exhibits
Networking Lunch - Offering an opportunity for clinicians to network and talk about assessment and treatment issues.
1:15 pm – 2:30 pm
Session 13: Medical Education Proposals for ME/CFS
Panel Chair: Susan Levine, M.D., Visiting Fellow, Cornell University, Ithaca, NY
Fellowship program for CFS/ME research (I)
Mady Hornig, M.D., Columbia University Medical Center
A fellowship training program for ME/CFS (II)
Anthony Komaroff, M.D., Harvard Medical School (retired)
Fellowship opportunity in ME/CFS (III)
Daniel Peterson, M.D., Simmaron Research
2:30 pm – 3:00 pm
Summary of the Conference
Anthony L. Komaroff, M.D.
3:00pm
Conference Concludes
October 27, 2016. IACFS/ME Conference Keynote Presentation
New ME/CFS Developments at the National Institutes of Health
Dr. Whittemore received her Ph.D. in anatomy from the University of Minnesota, followed by post-doctoral work at the University of California, Irvine, and a Fogarty Fellowship at the Karolinska Institute in Stockholm, Sweden. She was on the faculty of the University of Miami School of Medicine in The Miami Project to Cure Paralysis prior to working with several non-profit organizations including the Tuberous Sclerosis Alliance, Genetic Alliance, Citizens United for Research in Epilepsy (CURE), and the National Coalition for Health Professional Education in Genetics (NCHPEG). She also served a four-year term on the National Advisory Neurological Disorders and Stroke Council.
Dr. Whittemore has been a strong voice for increasing the research commitment for ME/CFS at the NIH. This includes launching a research protocol at the NIH Clinical Center to intensively study individuals with ME/CFS and re-invigorating the efforts of the Trans-NIH ME/CFS Research Working Group. The working group, co-chaired by Dr. Whittemore, consists of representatives from 23 NIH institutes that help to support extramural ME/CFS research. Dr. Vicky Whittemore is also the NIH representative to the U.S. Department of Health and Human Services' Chronic Fatigue Syndrome Advisory Committee.
PLENARY SPEAKER: Dr. Øystein Fluge, Chief Physician, Department of Oncology, Haukeland University Hospital, University of Bergen, Norway
Dr. Fluge is Chief Physician in the Department of Oncology at Haukeland University Hospital, University of Bergen, Norway. He received his medical degree in 1988 from the University of Bergen and has specialized in oncology since 2004. He has conducted research at the Surgical Institute and Department of Molecular Biology, University of Bergen and has been funded as a Research Fellow by the Norwegian Cancer Society.
In 2004, Dr. Fluge and his colleague, Dr. Olav Mella, a neurologist at the same institution, noticed that a patient’s ME/CFS symptoms improved substantially while undergoing chemotherapy treatment for a concurrent diagnosis of lymphoma. This was followed by a pilot study in 2009 with positive results. In 2011, Dr. Fluge, Dr. Mella, and their colleagues published a randomized double-blind placebo-controlled trial of rituximab in 30 ME/CFS patients demonstrating that two-thirds of the intervention group experienced moderate to major improvements in their ME/CFS symptoms. For a medical condition with no disease-modifying treatments, this was a ground-breaking study. Currently, they are in the midst of attempting to replicate their results in a larger Phase III multi-center study in Norway.
12th International IACFS/ME Biennial Clinical and Research Conference
Emerging Science and Clinical Care
Thursday, October 27th
9:30 am – 12:30 pm
Professional workshops (run concurrently; attendees select one only)
Review of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Fibromyalgia and Multiple Chemical Sensitivities/Environmental Sensitivities: Office Assessment and Management
Alison Bested, M.D., F.R.C.P.C.
Clinical associate professor, Department of Medicine, University of British Columbia
Acute and Chronic Enteroviral Infection
John Chia, M.D.
UCLA School of Medicine
How Cardiopulmonary Exercise Testing Informs Pathology and Treatment
Staci Stevens, M.A.
Founder, WorkWell Foundation
1:30 pm – 4:30 pm
Professional workshops (run concurrently; attendees select one only)
Behavioral Assessment and Treatment of ME/CFS and Fibromyalgia
Fred Friedberg, Ph.D.
President, IACFS/ME
Research Associate Professor, Stony Brook University
Founder and Editor, Fatigue: Biomedicine, Health and Behavior
Diagnosing and Treating Orthostatic Intolerance
Peter Rowe, M.D.
Johns Hopkins University School of Medicine
NIH Grant Writing Workshop
Vicky Whittemore, Ph.D.
Program Director, Channels, Synapses and Circuits
National Institute of Neurological Disorders and Stroke
General Session Agenda-Friday, October 28th
8:00 am – 8:15 am
Welcome and Introduction
Fred Friedberg, Ph.D.
President, IACFS/ME
Research Associate Professor, Stony Brook University
Founder and Editor, Fatigue: Biomedicine, Health and Behavior
8:15 am – 9:00 am (last 15 min. are Q and A)
Plenary Session
B-lymphocyte depletion and disease mechanisms in ME/CFS
Oystein Fluge, M.D.
Chief Physician, Department of Oncology,
Haukeland University Hospital, University of Bergen, Norway
Paper Sessions following short paper presentations each 12 minutes in length, presenters will field questions written on cards by the audience and given to the chair as time permits.
9:00 am – 10:15 am
Session 1: The Latest Research in Immunology and the Microbiome
Session Chair: Sonya Marshall-Gradisnik, Ph.D.
Professor of Immunology, Griffith University, Australia
Exercise testing highlights differences in cytokine profile and network between patients with chronic fatigue syndrome and healthy sedentary participants
Francois Haddad, M.D., Director, Biomarker and Phenotypic Core Laboratory, Stanford Cardiovascular Institute
A panel of biomarkers accurately identifies CFS/ME patients and contributes to the understanding of the pathophysiology of the disorder
Kenny L. De Meirleir, M.D., Nevada Center for Biomedical Research at University of Nevada
A profile of circulating cytokines is associated with disease severity in chronic fatigue syndrome patients
Jose G. Montoya, M.D., Stanford University School of Medicine
Alterations in the enteric bacterial and viral microbiome in ME/CFS
Ludovic Giloteaux, Ph.D., Department of Molecular Biology and Genetics, Department of Microbiology, Cornell University
10:15am – 10:45 am
Break/Visit Exhibits
10:45 am – 12:15 pm
Session 2: Treatment Studies and Clinical Practice
Chair: Daniel Peterson, M.D.
Griffith University, Gold Coast, Australia
Owner, Sierra Internal Medicine, Incline Village, Nevada
Reflections on the rituximab trials
Olav Mella, M.D., Department director/professor, Haukeland University Hospital, Oslo, Norway
Synergy Trial for CFS – a phase 2 study of low-dose methylphenidate plus mitochondrial support
Lucinda Bateman, M.D., Bateman Horne Center of Excellence
N-Acetylcysteine alleviates cortical glutathione deficit and improves symptoms in CFS:
An in vivo validation study using proton magnetic resonance spectroscopy
Dikoma Shungu, Ph.D., Departments of Radiology, Neurology and Neuroscience, Weill Cornell Medicine
A re-examination of the cognitive behavioral theory of CFS
Madison Sunnquist, DePaul University
Potential for an immunosignature assay to aid in classification and prediction of rituximab response in ME/CFS
David Patrick, M.D., FRCPC, MHSc, University of British Columbia School of Population and Public Health
12:15 pm – 1:45 pm
Lunch Break/Visit Exhibitors
Special Lunch Session: ME/CFS studies at the Centers for Disease Control and Prevention
Multi-site Clinic Assessment of ME/CFS (MCAM)
Chair: Elizabeth R. Unger, M.D., Ph.D.
Chief, Chronic Viral Diseases Branch
Centers for Disease Control and Prevention (CDC)
Study design of the multi-site clinic assessment of ME/CFS (MCAM)
Elizabeth R. Unger, M.D., Ph.D.
Jin-Mann S. Lin, Ph.D., Senior statistician/epidemiologist, US Centers for Disease Control and Prevention
Description of the Multi-site Clinic Assessment of ME/CFS (MCAM) Study
Mangalathu Rajeevan, Ph.D., Research Microbiologist, US Centers for Disease Control and Prevention
Data on cognitive function from Multi-Site Clinical Assessment of Myalgic Encephomyelitis/Chronic Fatigue Syndrome (MCAM) – Preliminary Analysis
Gudrun Lange, Ph.D., Consulting Clinical Neuropsychologist, Mount Sinai Beth Israel Pain and Fatigue Study Center.
Exercise testing data from the Multi-Site Clinic Assessment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (MCAM) Study
Dane Cook, Ph.D., Professor ofKinesiology, University of Wisconsin-Madison
Salivary test data from the Multi-site Clinic Assessment of Myalgic Encephomyelitis/Chronic Fatigue Syndrome (ME/CFS) (MCAM) Study
Jin-Mann S. Lin, Ph.D., Senior statistician/epidemiologist, US Centers for Disease Control and Prevention
Pilot study evaluating impact of sample processing and assay format on measured natural killer cell function
Troy Querec, Ph.D., Associate Service Fellow, Associate Service Fellow
1:45 pm – 2:45 pm
Session 3: Gulf War Illness
Session Co-chairs:
Kristy Lidie, Ph.D., US Department of Defense
Victor Kalisinsky, Ph.D., US Department of Veterans Affairs
Gulf War Illness Program Officers
Gulf war illness and chronic fatigue syndrome: lessons learned
Presenter: Lea Steele, Ph.D., Research professor, Baylor University Institute of Biomedical Studies
Brain Immune Interactions in Gulf War Illness: Cytokines and Cognition in US Military Veterans
Kimberly Sullivan, Ph.D., Boston University Medical Campus
Genomic approach to find mechanisms of Gulf War Illness pathobiology
Lubov Nathanson, Ph.D., Institute for Neuro Immune Medicine, Nova Southeastern University
Using gene expression signatures to identify novel treatment strategies in Gulf War Illness
Travis Craddock, Ph.D., Department of Psychology & Neuroscience, Nova Southeastern University
2:45 pm – 3:15pm
Break/Visit Exhibits
3:15 pm – 5:15 pm
Session 4: Diagnosing CFS/ME; Difficult Clinical Cases: Focus on Fatigue and Pain
Session Chair: Nancy Klimas, M.D.
Immediate Past President, IACFS/ME
Professor of Medicine & Director, Nova Southeastern University
Director, Miami VAMC Gulf War Illness & ME/CFS Research Program
Panel:
Lucinda Bateman, M.D., Bateman Horne Center of Excellence, Utah
John Chia, M.D., UCLA School of Medicine
Charles Lapp, M.D., Hunter-Hopkins Center, North Carolina
Dan Peterson, M.D., Sierra Internal Medicine, Incline Village, Nevada
Katherine Rowe, M.D., Royal Children's Hospital , Australia
Peter Rowe, M.D., Johns Hopkins University School of Medicine
5:15 pm – 6:00 pm
Visit Poster Presentations/Exhibits
Evening Session
6:30 pm – 8:30 pm
Common Data Elements (CDEs) for Standardized Testing and Clinical Studies
Chair: Vicky Whittemore, Ph.D.
Program Director, Channels, Synapses and Circuits
National Institute of Neurological Disorders and Stroke
The National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health and the Center for Disease Control and Prevention (CDC) will partner to develop common data elements (CDEs) for standardized testing and common data elements to be recorded in clinical studies/trials of individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The development of CDEs for ME/CFS will facilitate the comparison of results across studies and help to standardize analysis. The session will be led by NINDS and CDC Program Staff to discuss the timeline and process for developing the CDEs and to obtain feedback and input from ME/CFS stakeholders.
General Session Agenda-Saturday, October 29th
8:00 am – 9:00 am
Session 5: CFS, SEID, ME Case Definitions: Clinical vs. Research Criteria
Presenter: Leonard Jason, Ph.D.
Professor, DePaul University, Director of the Center for Community Research
Discussants:
Lucinda Bateman, M.D.
Chief Medical Officer
Bateman Horne Center of Excellence
Salt Lake City, Utah
Jon Kaiser, M.D.
IACFS/ME Board Member
University of California, San Francisco
9:00 am – 10:00 am
Session 6: Symptom Provocation Studies I
Chair: Staci Stevens, M.A.
Founder, WorkWell Foundation
Cardiopulmonary exercise testing demonstrates post-exertional chronotropic incompetence
Mark Van Ness, Department of Health, Exercise, and Sport Science, University of the Pacific
Post-exertional malaise: multiple and unexpected symptoms, sometimes delayed, often prolonged
Lily Chu, M.D., Stanford University School of Medicine
Cognitive function in adolescents with chronic fatigue syndrome/myalgic encephalomyelitis:
A novel paradigm
Sarah Knight, Ph.D., Murdoch Children’s Research Institute, Australia
10:00 am – 10:30 am
Break/Visit Exhibits
10:30 am – 12:00 pm
Session 7: Public Health Research
Chair: Steve Krafchick, MPH, JD
IACFS/ME Board Member
Estimating rates of pediatric chronic fatigue syndrome and myalgic encephalomyelitis in a community-based sample
Leonard A. Jason, Ph.D., DePaul University
Two year follow-up of impaired range of motion in adolescent chronic fatigue syndrome
Peter C. Rowe, M.D., Johns Hopkins University School of Medicine
Allergic disorder phenotypes in ME/CFS and patterns of medical comorbidity and clinical dysfunction
Susan Levine, M.D., Cornell Medical Center, New York City
Exploring the role of sex hormones in driving symptom severity in ME/CFS
Gordon Broderick, Ph.D., Department of Medicine, University of Alberta
Nurses’ acute fatigue predicts sickness absence in the workplace: a 1-year retrospective cohort study
Knar Sagherian, RN, MSN, University of Maryland School of Nursing
Examining the accuracy of a physical diagnostic technique for chronic fatigue syndrome/myalgic encephalomyelitis: a blind controlled study
Ray Perrin, DO, Ph.D., Honorary Senior Lecturer: Allied Health Professions Research Unit, University of Central Lancashire, UK
12:00 pm – 1:30 pm
Lunch Break/Visit Exhibits
Lunch Panel
Special Interest Groups: International Research Networks
David Patrick, Ph.D., Moderator
Professor and Director
School of Population and Public Health
University of British Columbia, Canada
European network on myalgic encephalomyelitis/chronic fatigue syndrome (EUROMENE)
Eliana Lacerda, M.D., Ph.D., Assistant Professor, London School of Hygiene & Tropical Medicine
The case for stratification in ME/CFS: Experience from the UK ME/CFS Biobank
Luis Nacul, M.D., Ph.D.
London School of Hygiene & Tropical Medicine
1:30 pm – 2:30 pm
Session 8: Research on Autonomic Functioning and Comorbidities
Chair: Peter Rowe, M.D., Johns Hopkins University School of Medicine
Postural tachycardia in chronic fatigue syndrome induced by exercise
Madison Keefe, B.S., Georgetown University
Distribution of dolorimetry in CFS, FM, GWI and control women
Amber Surian, M.S., Department of Medicine, Georgetown University
Truncal ataxia is an unrecognized cause of orthostatic intolerance in patients with myalgic encephalomyelitis
Kunihisa Miwa, M.D.
Miwa Naika Clinic, Japan
2:30 pm – 3:30 pm
Session 9: Advances in Brain Research and Neurological Studies
Chair: Anthony L. Komaroff, M.D., Professor of Medicine, Harvard Medical School (retired)
Assessment of neurobiological dysfunction in chronic fatigue syndrome
Ben Natelson, M.D.
Pain & Fatigue Study Center, Mount Sinai Beth Israel
Disrupted functional connectivity in Gulf War illness (GWI)
James N. Baraniuk, M.D., Department of Medicine, Georgetown University
Functional neural consequences of post-exertion malaise in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
Dane B. Cook, Ph.D., University of Wisconsin-Madison
3:30 pm – 4:00 pm
Break/Visit Exhibits
4:00 pm – 5:00 pm
Visit Poster Presentations/Exhibits
5:00 pm – 6:00 pm
IACFS/ME Membership Business Meeting
6:00 pm – 7:00 pm
IACFS/ME Social/Cocktails Hour
7:00 pm – 8:00 pm
IACFS/ME Banquet Dinner
8:00 pm – 9:00 pm
Awards Presentation
General Session Agenda-Sunday, October 30th
8:00 am – 9:15 am
Session 10: Symptom Provocation Studies II
Chair: Betsy Keller, Ph.D.
Department of Exercise and Sport Sciences, Ithaca College
Blood lactate increases more rapidly after a previous exercise challenge in patients with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) than in healthy subjects
Katarina Lien, M.D., Ph.D., University of Oslo
Subsets of ME/CFS patient responses to a 2-day CPET
Betsy Keller, Ph.D., Department of Exercise and Sport Sciences, Ithaca College
Neuromuscular Strain Increases Symptom Intensity in Chronic Fatigue Syndrome
Peter Rowe, M.D, Johns Hopkins University School of Medicine
Polar Metabolites Distinguish ME/CFS Patients and Controls
Maureen Hanson, Ph.D., Department of Molecular Biology and Genetics, Cornell University
9:15 am – 10:30 am
Session 11: Genetics Research
Chair: Jose Montoya, M.D.
Professor of Medicine, Stanford University Medical Center
Single nucleotide polymorphisms in myalgic encephalomyelitis: possible genetic factors influencing pathophysiology
Benjamin Eike, B.A., Nova Southeastern University, College of Osteopathic Medicine
Using gene expression modules to identify gender specific treatments in myalgic encephalomyelitis/chronic fatigue syndrome
Mary G. Jeffery, Institute for Neuro-Immune Medicine, Nova Southeastern University
Epigenetic modifications and glucocorticoid sensitivity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
Wilfred de Vega, Ph.D. Can.
University of Toronto
ME/CFS miRNA analysis, mRNA in-situ hybridization and STAT1 localization upon stress trigger
Paula A. F. Waziry, Ph.D., Institute of Neuro Immune Medicine, Nova Southeastern University
Genomics of chronic fatigue syndrome reveals systemic inflammatory response
Jose G. Montoya. M.D., Stanford University School of Medicine
10:30 am – 10:45 am
Break
10:45 am – 12:15 pm
Session 12: Panel Discussion
“Nothing about us without us:” How community-engaged research can accelerate progress in the field of ME/CFS
Moderator: Lily Chu, M.D., MSHS, Co-Vice President, IACFS/ME; Collaborator, Stanford ME/CFS Initiative
Speaker: William Elwood, Ph.D., Expert, community-engaged research, US National Institutes of Health (NIH) Member, Trans-NIH Working Group for ME/CFS
Panelists
Jin-Mann Lin, Ph.D., Senior statistician/epidemiologist, US Centers for Disease Control and Prevention
Leonard Jason, Ph.D., Professor of community psychology, DePaul University (Chicago, Illinois)
Sonya Chowdhury, Chief Executive, Action for M.E.; Member, United Kingdom ME/CFS Research Collaborative
Jennifer Spotila, J.D., FDA Patient Representative; former chairman, Solve ME/CFS Initiative Board of Directors
12:15 pm – 1:15 pm
Lunch/Visit Exhibits
Networking Lunch - Offering an opportunity for clinicians to network and talk about assessment and treatment issues.
1:15 pm – 2:30 pm
Session 13: Medical Education Proposals for ME/CFS
Panel Chair: Susan Levine, M.D., Visiting Fellow, Cornell University, Ithaca, NY
Fellowship program for CFS/ME research (I)
Mady Hornig, M.D., Columbia University Medical Center
A fellowship training program for ME/CFS (II)
Anthony Komaroff, M.D., Harvard Medical School (retired)
Fellowship opportunity in ME/CFS (III)
Daniel Peterson, M.D., Simmaron Research
2:30 pm – 3:00 pm
Summary of the Conference
Anthony L. Komaroff, M.D.
3:00pm
Conference Concludes
