SOC
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... but like everything else I thought wasn't my particular problem, I do have methylation issues. I'm trying to get up to speed, but now is not my best time cognitively to be doing new reading/research, so I'm hoping to pick some brains.
My B12 is high and doesn't drop much even if I don't take any B12. My D 25-OH is low and increases only slowly with 7500 units sublingually daily. My folate has not been tested. Daughter has the same pattern along with high blood folate. We don't have her genetic test results yet.
Based on my MTHFR mutation, my doc is currently suggesting methylfolate and hydroxy B12, which is consistent with advice I've gotten here. (Go team PR!)
Here's the part I'm unclear about... I'm having a hard time finding a multi without either methyl B12 or cyano B12. The cyano B12 is out, but I'm wondering if the methyl B12 is okay for me along with hydroxy B12. Does the balance between the two matter?
Also, I'm seeing recommendations to start the methylfolate first, then add the B12. Is this important enough for me to avoid taking my multi or Jarrow B-Right for a period of time? If so, for how long?
Is 400 mcg a sufficient amount of methyl folate to start with?
Thanks again to those who have already advised me on some of this.
Homozygous
MAO A R297R rs6323 TT+/+
BHMT-08 rs651852 TT+/+
CBS A360A rs1801181 AA+/+
Heterozygous
COMT V158M rs4680 AG+/-
COMT H62H rs4633 CT+/-
VDR Bsm rs1544410 CT+/-
VDR Taq rs731236 AG+/-
MTHFR C677T rs1801133 AG+/-
MTRR K350A rs162036 AG+/-
BHMT-02 rs567754 CT+/-
My B12 is high and doesn't drop much even if I don't take any B12. My D 25-OH is low and increases only slowly with 7500 units sublingually daily. My folate has not been tested. Daughter has the same pattern along with high blood folate. We don't have her genetic test results yet.
Based on my MTHFR mutation, my doc is currently suggesting methylfolate and hydroxy B12, which is consistent with advice I've gotten here. (Go team PR!)
Here's the part I'm unclear about... I'm having a hard time finding a multi without either methyl B12 or cyano B12. The cyano B12 is out, but I'm wondering if the methyl B12 is okay for me along with hydroxy B12. Does the balance between the two matter?
Also, I'm seeing recommendations to start the methylfolate first, then add the B12. Is this important enough for me to avoid taking my multi or Jarrow B-Right for a period of time? If so, for how long?
Is 400 mcg a sufficient amount of methyl folate to start with?
Thanks again to those who have already advised me on some of this.
Homozygous
MAO A R297R rs6323 TT+/+
BHMT-08 rs651852 TT+/+
CBS A360A rs1801181 AA+/+
Heterozygous
COMT V158M rs4680 AG+/-
COMT H62H rs4633 CT+/-
VDR Bsm rs1544410 CT+/-
VDR Taq rs731236 AG+/-
MTHFR C677T rs1801133 AG+/-
MTRR K350A rs162036 AG+/-
BHMT-02 rs567754 CT+/-