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Hypothesis: inflammatory acid-base disruption underpins Long Covid

Violeta

Violeta

Senior Member
Messages
2,969
Based on these data, we hypothesize that the shift to anaerobic respiration causes an acid-base disruption that can affect every organ system and underpins the symptoms of PASC. This hypothesis can be tested by longitudinally evaluating acid-base markers in PASC (Post-Acute Sequelae of COVID-19) patients and controls over the course of a month. If our hypothesis is correct, this could have significant implications for our understanding of PASC and our ability to develop effective diagnostic and therapeutic approaches.

SARS-CoV-2 proteins also directly cause metabolic changes (5) similar to hypoxia, increasing anaerobic respiration and the generation of lactate and protons.


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140510/
 
SWAlexander

SWAlexander

Senior Member
Messages
1,946
Violeta said:
similar to hypoxia, increasing anaerobic respiration and the generation of lactate and protons.
Click to expand...
If I understand this right, anaerobic respiration is a way for cells to produce energy without using oxygen.
When oxygen levels are low, cells switch from aerobic respiration (which requires oxygen) to anaerobic respiration. This process is less efficient at generating energy and results in the production of lactate (or lactic acid) and protons (H+ ions).
The accumulation of lactate and protons in the muscles is often associated with muscle fatigue and the "burn" feeling during intense exercise. This response is a temporary adaptation to a low-oxygen environment, allowing cells to continue producing energy until normal oxygen levels are restored.

In my case diagnosed with Post Polio (PPS) and extensive research, individuals may experience decreased muscle strength and endurance. This could lead to a greater reliance on anaerobic respiration during physical activity, as weakened muscles might be less efficient in utilizing oxygen for aerobic respiration. When muscles can't get enough oxygen to perform aerobic respiration, they switch to anaerobic respiration, leading to an increase in lactate production, which is often associated with muscle fatigue and discomfort.
 
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Violeta

Violeta

Senior Member
Messages
2,969
Still looking, but does anyone know how viral proteins mediate metabolic reprogramming?

Does anyone test their saliva and urine pH?

"In addition, viral proteins have been found in the brain (3, 17) and may mediate metabolic reprogramming, inflammation and hypoxia."
 
SWAlexander

SWAlexander

Senior Member
Messages
1,946
Unfortunately, there is no possibility in Germany. Or better said, German doctors declare that "there is no need for this kind of test".
 
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