Hypothalamic Dysfunction Theory + studies

[Violeta]

That's so interesting, and led me to this study.

Immunomodulatory Effects of Dopamine in Inflammatory Diseases

https://pubmed.ncbi.nlm.nih.gov/33897712/

Edit in:
Recently, the role of the DA receptor in inflammation has been widely studied, mainly focusing on NLRP3 inflammasome,

"With detailed descriptions of their roles in Parkinson disease, .......rheumatoid arthritis,"

I have intermittently had rheumatoid arthritis symptoms, and have had it again for the past two weeks. So when I saw "rheumatoid arthritis" in the study about the DA receptor along with NLRP3, (which I had been meaning to look into at greater depth), and also rereading "Uric Acid as a Factor in the Causation of Disease" because of it's view on RA, I looked up uric acid plus NLRP3 and found this.

I didn't expect to find it because when you look up NLRP3 you see that it's mostly talked about in relation to viruses.

Soluble Uric Acid Activates the NLRP3 Inflammasome

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233987/

Wow!

https://pubmed.ncbi.nlm.nih.gov/25594175/

Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome

 

[Ali_Mardiyev]

https://www.google.com/url?sa=t&sou...QQFnoECBcQAQ&usg=AOvVaw1659RfsHdfFJg1r2FsSVdx
Interesting theory how tryptophan supplementation suppresses Th1 and Th17 cells.

Wow!

https://pubmed.ncbi.nlm.nih.gov/25594175/

Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome

I genuinely think, that dopamine is extremely important in understanding our disease.
I was initially sceptical about Ron Davis's theory, but tryptophan accumulation may lead to excessive serotonin, which in turn may put us in an imbalanced neurotransmitter state, with low dopamine signalling. This could explain some of the symptoms we experience.
Another interesting thing is that, the girl, that went and has stayed(6 months) in remission, followed a "golder autoimmune" diet, which was fairly low in animal protein, and used LDA, which upregulates dopamine receptors.

 

[Violeta]

Have you tried taking tyrosine? Tyrosine is a precursor to dopamine. I started taking it a while ago after reading some posts about it here. It has made an amazing difference. I also have issues related to norepinephrine, which you mentioned in an earlier message.

I have low blood pressure and most of the time, especially when in a flare, low brain power.

 

[Ali_Mardiyev]

Have you tried taking tyrosine? Tyrosine is a precursor to dopamine. I started taking it a while ago after reading some posts about it here. It has made an amazing difference. I also have issues related to norepinephrine, which you mentioned in an earlier message.

I have low blood pressure and most of the time, especially when in a flare, low brain power.

I'm honestly a bit scared of taking supplements right now, after my body's awful reaction to magnesium glycinate.
I plan to take a dopamine raising agent(probably abilify) in the future.
I'm currently gaining as much information as I can, so I can hit this disease from different angles. I plan to do another blood test, brain and adrenal gland MRI in the near future.
My main problem is inverted circadian rhythm(I sleep in the afternoon), and I can't relax at night. Every living minute I'm thinking/searching about this disease. It probably created an OCD type condition in me.
But I'm only 20 years old, and I'm afraid of living my live like this.

 

[Violeta]

https://www.google.com/url?sa=t&sou...QQFnoECBcQAQ&usg=AOvVaw1659RfsHdfFJg1r2FsSVdx
Interesting theory how tryptophan supplementation suppresses Th1 and Th17 cells.
I genuinely think, that dopamine is extremely important in understanding our disease.
I was initially sceptical about Ron Davis's theory, but tryptophan accumulation may lead to excessive serotonin, which in turn may put us in an imbalanced neurotransmitter state, with low dopamine signalling. This could explain some of the symptoms we experience.
Another interesting thing is that, the girl, that went and has stayed(6 months) in remission, followed a "golder autoimmune" diet, which was fairly low in animal protein, and used LDA, which upregulates dopamine receptors.

The diseases in a presentation for the Goldner autoimmune diet, (lupus, MS) are mentioned in this study about dopamine.

https://pubmed.ncbi.nlm.nih.gov/33897712/

And the diet recommends avoiding all animal protein, does not include beans, both high purine containing foods. So the diet cuts out purines.

And also notice in that study, that, "Recently, the role of the DA receptor in inflammation has been widely studied, mainly focusing on NLRP3 inflammasome, NF-κB pathway, and immune cells."

So the diet stops the inflammation of those autoimmune diseases by cutting out uric acid which causes activation of NLRP3.

 

[VisualEffect]

Another substance that came up recently was:

Guanfacine- when combined with NAC, this is supposedly benefit focus and attention ADHD and something was published last week about taking it for long covid brain fog.

My GP did not sound very excited about the idea of taking anything like that. But we did not discuss in detail.

Info about that study here:

https://www.healthrising.org/blog/2022/12/24/brain-fog-long-covid-chronic-fatigue-fibromyalgia/

One ME/CFS hypothesis proposes that damage to the prefrontal cortex has removed an inhibitory brake on the limbic system in ME/CFS. The resulting hyperarousal and hypervigilance causes their autonomic nervous systems to react to the slightest stimuli, leaving them tired and wired.

Very accurate definition! It really feels like inhibitory processes aren't working well in ME/POTS/dysautonomia. But damaged center could be anywhere, because ANS is controlled by so many parts of the brain. Prefrontal cortex or somewhere in hypothalamospinal tract.
I fear, how medicine could help us, in that case.

 

[Rufous McKinney]

But I'm only 20 years old, and I'm afraid of living my live like this.

My sense is you are going to "figure this out" and improve. Keep doing what your doing (with rest breaks).

 

[Ali_Mardiyev]

The diseases in a presentation for the Goldner autoimmune diet, (lupus, MS) are mentioned in this study about dopamine.

https://pubmed.ncbi.nlm.nih.gov/33897712/

And the diet recommends avoiding all animal protein, does not include beans, both high purine containing foods. So the diet cuts out purines.

And also notice in that study, that, "Recently, the role of the DA receptor in inflammation has been widely studied, mainly focusing on NLRP3 inflammasome, NF-κB pathway, and immune cells."

So the diet stops the inflammation of those autoimmune diseases by cutting out uric acid which causes activation of NLRP3.

My sense is you are going to "figure this out" and improve. Keep doing what your doing (with rest breaks).

Thank you very much! I hope you'll get better too!
I found a thread on reddit(social media) where the say, that immunoadsorbtion helped a good amount of Covid long Hauler's and some CFS/ME sufferers. One guy reported from sitting in the dark all day, not being able to handle any stimuli, to driving 100 miles every day and being able to walk 6000 steps. Whether the effect is long lasting we don't know. But apparently it's working, though expensive. 5 procedurses cost 11k euros and it's done in Germany.
I also figured out, why that girl(whose story I covered before) went into remission. The diet, that she followed is heavily concentrated on detoxing. As we know almost all of CFS/ME sufferers have high heavy metal levels in their body. Which I believe could also cause our symptoms.
See this study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153245/

 

[Violeta]

@Ali_Mardiyev , have you seen Suzanne Vernon's article about CRFR1 and CRFR2? Here's the study.

They tested a drug, CT38, which is a CRFR2 agonist, and had encouraging results. The drug is not on the market yet.

I can't find a natural agonist, but CRFR1 antagonists can help the situation. Panax ginseng, especially when taken with ginkgo biloba, might be just as helpful. I am having good results with them.

https://www.frontiersin.org/articles/10.3389/fnsys.2021.698240/full

Acute Corticotropin-Releasing Factor Receptor Type 2 Agonism Results in Sustained Symptom Improvement in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

 

[Ali_Mardiyev]

@Ali_Mardiyev , have you seen Suzanne Vernon's article about CRFR1 and CRFR2? Here's the study.

They tested a drug, CT38, which is a CRFR2 agonist, and had encouraging results. The drug is not on the market yet.

I can't find a natural agonist, but CRFR1 antagonists can help the situation. Panax ginseng, especially when taken with ginkgo biloba, might be just as helpful. I am having good results with them.

https://www.frontiersin.org/articles/10.3389/fnsys.2021.698240/full

Acute Corticotropin-Releasing Factor Receptor Type 2 Agonism Results in Sustained Symptom Improvement in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

@Ali_Mardiyev , have you seen Suzanne Vernon's article about CRFR1 and CRFR2? Here's the study.

They tested a drug, CT38, which is a CRFR2 agonist, and had encouraging results. The drug is not on the market yet.

I can't find a natural agonist, but CRFR1 antagonists can help the situation. Panax ginseng, especially when taken with ginkgo biloba, might be just as helpful. I am having good results with them.

https://www.frontiersin.org/articles/10.3389/fnsys.2021.698240/full

Acute Corticotropin-Releasing Factor Receptor Type 2 Agonism Results in Sustained Symptom Improvement in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

After my last post on here, I made a lot of research and onе of the main problems of most ME/CFSers is low acetylcholine.
Acetylcholine is the primary neurotransmitter of the parasympathetic(rest and digest) nervous system and also stimulates the vagus nerve, which I believe to be dysfunctional in most of us. Panax Ginseng and Ginkgo Biloba both raise acetylcholine levels. That's probably why you got significant benefits from them.
Acetylcholine slows the heart rate, improves gi motility, promotes glandulary secretions(saliva, sweat), plays an important role in memory, concentration, arousal etc.
Have you ever tried Alpha GPC or CDP Choline. Imo they are more bioavailable choline sources. Also do you take a B vitamin complex, particularly Pantothenic acid(B5)? It has shown to improve adrenal gland function and raise choline levels in the body
Lastly, can you describe your history of disease(age, duration, severity) and supplements you have tried?

 

[Ali_Mardiyev]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC38410/pdf/pnas01523-0495.pdf