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@Campainger, regarding the quote in bold above: do you know if www.tpauk.com were able to demonstrate that these ME/CFS patients had conditions that stop thyroid hormone from being properly utilized? For example, did the patients have lab results showing high reverse T3, which blocks the effect of T3??.[/quote]
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Some patients had lab results showing high levels of reverse T3. Some did their own calculation. See 'Patients Stories' in 'Treasure Chest' www.tpauk.com
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I would like to see some case histories of these ME/CFS patients who improved when given T3, with their thyroid hormone and cortisol lab reports indicating that they had high reverse T3.
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You can find some such stories in our website under 'Patients Stories' HERE
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Would you know of any other conditions that stop thyroid hormone from being properly utilized, in addition to high reverse T3?
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The main conditions that stop thyroid hormone from working are as follows - and there may be others: For more detail see HERE
1. Thyroxine dose is too low.
Often this is the case, and the doctor won’t increase it, since the blood levels appear okay. Sometimes,the dose of T4 is quite high – 200 mcg – 300 mcg – but you still don’t feel well.
2. Partial response to the single synthetic thyroxine replacement.
Your thyroid produces 4 other hormones apart from thyroxine, and most of us need them all. Without them our response is limited and synthetic T4 may not suit the system as well as the natural thyroid hormones.
3. Adrenal fatigue or exhaustion.
The production of T4, its conversion to T3, and the receptor uptake requires a normal amount of adrenal hormones, notably cortisone. (Excess cortisone can shut production down, however).
4. Failure of the 5 de-iodinase enzyme.
This is what happens if the adrenals are not responding properly, and provision of cortisone usually switches it on again.
5. Receptor resistance.
Being hypothyroid for some considerable time may mean the biochemical mechanisms which permit the binding of T3 to the receptors is downgraded; the T3 just won’t go in.
6. Food allergies.
e.g. allergy to gluten, the protein fraction of wheat. The antibody generated by the body, by a process of molecular mimicry, cross reacts with the thyroperoxidase enzyme, (which makes thyroxine) and shuts it down. So allergy to bread can make you hypothyroid.
7. Presence of systemic candidiasis.
This is where candida albicans, a yeast, which causes skin infections almost anywhere in the body, invades the lining of the lower part of the small intestine and the large intestine.
8. Hormone imbalances.
The whole of the endocrine system is linked; each part of it needs the other parts to be operating normally to work properly.
9. Low Levels of Specific Nutrients
Iron, transferrin saturation%, ferritin, vitamin B12, vitasmin D3, magnesium, folate, copper and zinc.
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Some people are calling this state Reverse T3 dominance, or Wilson's Syndrome. Though this is a controversial concept with little evidence behind it.
______________________________________
Here is a bit more information regarding ReverseT3 dominance:
http://tpauk.com/forum/content.php?799-THYROID-HORMONE-RESISTANCE-RT3
http://tpauk.com/forum/content.php?737-Reverse-T3-and-Reverse-T3-Dominance
http://tpauk.com/forum/content.php?736-What-Should-We-Do-About-rT3
http://tpauk.com/forum/content.php?735-How-To-Calculate-Your-Level-Of-Reverse-T3
http://tpauk.com/forum/content.php?503-Do-you-Have-Tissue-Resistance-To-Thyroid-Hormones
_______________________________
Some patients had lab results showing high levels of reverse T3. Some did their own calculation. See 'Patients Stories' in 'Treasure Chest' www.tpauk.com
_________________________________
I would like to see some case histories of these ME/CFS patients who improved when given T3, with their thyroid hormone and cortisol lab reports indicating that they had high reverse T3.
_________________________________
You can find some such stories in our website under 'Patients Stories' HERE
___________________________
Would you know of any other conditions that stop thyroid hormone from being properly utilized, in addition to high reverse T3?
___________________________
The main conditions that stop thyroid hormone from working are as follows - and there may be others: For more detail see HERE
1. Thyroxine dose is too low.
Often this is the case, and the doctor won’t increase it, since the blood levels appear okay. Sometimes,the dose of T4 is quite high – 200 mcg – 300 mcg – but you still don’t feel well.
2. Partial response to the single synthetic thyroxine replacement.
Your thyroid produces 4 other hormones apart from thyroxine, and most of us need them all. Without them our response is limited and synthetic T4 may not suit the system as well as the natural thyroid hormones.
3. Adrenal fatigue or exhaustion.
The production of T4, its conversion to T3, and the receptor uptake requires a normal amount of adrenal hormones, notably cortisone. (Excess cortisone can shut production down, however).
4. Failure of the 5 de-iodinase enzyme.
This is what happens if the adrenals are not responding properly, and provision of cortisone usually switches it on again.
5. Receptor resistance.
Being hypothyroid for some considerable time may mean the biochemical mechanisms which permit the binding of T3 to the receptors is downgraded; the T3 just won’t go in.
6. Food allergies.
e.g. allergy to gluten, the protein fraction of wheat. The antibody generated by the body, by a process of molecular mimicry, cross reacts with the thyroperoxidase enzyme, (which makes thyroxine) and shuts it down. So allergy to bread can make you hypothyroid.
7. Presence of systemic candidiasis.
This is where candida albicans, a yeast, which causes skin infections almost anywhere in the body, invades the lining of the lower part of the small intestine and the large intestine.
8. Hormone imbalances.
The whole of the endocrine system is linked; each part of it needs the other parts to be operating normally to work properly.
9. Low Levels of Specific Nutrients
Iron, transferrin saturation%, ferritin, vitamin B12, vitasmin D3, magnesium, folate, copper and zinc.
______________________________________
Some people are calling this state Reverse T3 dominance, or Wilson's Syndrome. Though this is a controversial concept with little evidence behind it.
______________________________________
Here is a bit more information regarding ReverseT3 dominance:
http://tpauk.com/forum/content.php?799-THYROID-HORMONE-RESISTANCE-RT3
http://tpauk.com/forum/content.php?737-Reverse-T3-and-Reverse-T3-Dominance
http://tpauk.com/forum/content.php?736-What-Should-We-Do-About-rT3
http://tpauk.com/forum/content.php?735-How-To-Calculate-Your-Level-Of-Reverse-T3
http://tpauk.com/forum/content.php?503-Do-you-Have-Tissue-Resistance-To-Thyroid-Hormones