Hi @ebethc betaine is trimethyl glycine a methyl doner, I am really not up on all the methylation stuff but that could be part of the wide awake thing.
I find that it works really well for me. I had about 12 yrs of SIBO bubbling away every night like a fermentation vessel and having lots of pain from trapped gasses.
I tried a lot of dietary modification and probiotics and so on, following advice from people such as Dr Myhill and Grace Liu's on SIBO but found that for me that betaine HCL was the last step in solving SIBO.
At the time I was eating a low available carbohydrate high fibre diet with probiotics, ox bile and digestive enzymes. When I started on the betaine HCL I needed 7 x 650mg tablets per meal I am now (two years later) down to 3 - 4 tablets per meal.
Acid does a lot, it enables you to better absorb nutrients and triggers the release of bile and digestive enzymes. For people who are treated soon it may well be enough to set them on a path to recovery. But when I got rid of the SIBO I still had issues with digestion.
I was still producing food coloured stools whenever I stopped taking the ox bile, and that only changed when I was treated for B hominis in December last year (triple therapy), and the stools were mostly bristol 7 for all of that time are getting much closer to bristol 4 now that I am taking antifungals.
I think most of my microbes must have been fungi. My slurries (thick bristol 7s) had been very well fermented and my very occasional stools had just floated as they are meant to. When I started taking nystatin I went to mostly bristol 2 - 4 and everything sank without any sign of fermentation.
... I also suspect that my sinuses were perhaps providing a resevoir for the fungi and bacteria that were a problem. I had very much improved stools when taking dental probiotics and oral nilstat last year, and am currently on a complicated regimen of nasal rinses and swabs and antifungal and probiotics to try to deal with this source of chronic infection.
One other issue re digestion that you may wish to look at is choline. To work properly the gut also has to move properly. http://forums.phoenixrising.me/inde...se-acetylcholine-at-low-cost-naturally.46037/.
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Great feedback, Richard! I was hoping that I am slowly but surely "reverse engineering" my problems... e.g. Killing gut bugs/SIBO until I get to root cause - digestive problems
Do u like bile better than betaine? Btw, great insight re methylation... I went down that road a couple of years ago w testing and protocols w/o a ton of success but it was still interesting to find some issues, e.g. Glycine, choline... Sam-e was helpful for awhile, prob because it degrades histamine - which is a huge issue for me
I'm not familiar Bristol testing ... what is it?
What did u use to kill SIBO? I used herbs, which has been effective... I'd like to do more...
What do u use in your sinuses? (If anything) I have a Neti pot and would like to find some anti microbial herbs for sinuses similar to what I used in my gut... currently just using cromolyn- saline wash.
What do you know about systemic enzymes? Wobenzym has been a big turning point for me... when inflammation is down, I feel like a normal person, at least for a few hours a day... the enzymes are pancreatic (in part) and they help dissolve protein particles & cytokines
Lol re the SIBO bubbling away... that's just what it feels like