How much CoQ10 do you take?

[mgk]

Has anyone tried the different formulations of CoQ10? Here's a graph I pulled from a study which tested a single 120mg dose of a few different ones:

• Product A is "Vesisorb." Example on iHerb.
• Product B and D use a different absorption-enhancing mechanism. Probably something like this or this. The study is sparse on details about the difference between the two.
• Product C is similar to most products on the market. Example.

Note that this study was funded by the company that makes Vesisorb so take it with a grain of salt.

 

[L'engle]

@mgk I've tried a few and found them different. Jarrow and Enzymatic therapy had noticeable effects. Many of the inferior brands from health food stores had no effect or caused a headache.

 

[mgk]

@mgk I've tried a few and found them different. Jarrow and Enzymatic therapy had noticeable effects. Many of the inferior brands from health food stores had no effect or caused a headache.

That doesn't surprise me anymore - brands seem to vary wildly for whatever reason. With CoQ10 there's more to the story though. Because of its chemical properties it's hard to absorb in general so there are a few different modifications they make to it in order to increase absorption. The study was done to determine the efficacy of these modifications, not as a brand comparison of the same product.

 

[dadouv47]

Hello,
After reading Myhill's book, I started taking CoQ10 ( Ubiquinol) twice a day (2x100).
It's only been 3 days and I feel that I have more energy ( not sure it comes from the CoQ10, in general supplements never helps me, but the improvement is quite impressive). On the other end, my heart beats pretty fast and it's really annoying, even when i'm in bed trying to sleep. Someone already experienced that kind of side effect from CoQ10?
Thanks the for the attention
David

 

[erin]

Initially I had a very good results with CoQ10. I had the fast heart beat too but this was resolved eventually. (I take beta blockers too.)

However, within 3 to 5 weeks of taking CoQ10 I gradually developed a rush on my shins. I didn't stopped the Q10 as I benefited so much. I thought the rash would settle eventually and it didn't. It got worse.

I think with every supplement one should use it with care. If you think you are sensitive reduce the dose if you can. I was indulging in my high energy, it's high for me though, probably normal to healthy ones.

I am trying astaxanthin recently. Not high doses, it's fine except it increased my appetite. Not sure if this is good. I have a normalish weight. But my mobility is not so great, I don't want to get heavy. So I'll play by the ear.

 

[dadouv47]

thanks for sharing your experience. How much Q10 were you taking?
I think i will try with only 100mg/day and see how i will react. I'm very sensitive to every supplement, but for once i feel that this one is really helping me ( besides heart beat, and maybe some anxiety/feeling weird but not sure if it comes from Q10 or other medication)

 

[erin]

I was taking 200 mg a day.

 

[AndyPandy]

I have been taking 75mg CoQ10 (ubidecarenone - Blackmores CoQ10) per day for a few years now with no noticeable adverse effects.

My ME/CFS Specialist and Naturopath wanted me to increase it to 300mg per day.

I recently tried it at 150mg (75 x 2) per day but just couldn't tolerate it - major increase in pain and fatigue, feeling poisoned and deeply ill, feeling "buzzy", shaky, mobility much worse.

Higher doses clearly not for me.

Have been told to try ubiquinol and PQQ, so will see how that goes after I recover from increasing the CoQ10.

Best wishes Andy

 

[Kierkegaard]

Any difference in ubiquinol vs ubiquinone for people here?

 

[ljimbo423]

Any difference in ubiquinol vs ubiquinone for people here?

I have used both and they both help to some degree. I took 50-100mg a day of ubiquinol for about a year and found it worked the same as the ubiquinone, at a much lower dose. I continue to take the ubiquinone at a dose of 230mg a day.

As far as cost goes, it seems to me they are about equal. The ubiquinol is much more expensive, but also much more potent. I have read that ubiquinol raises blood levels of coq10 (ubiquinone) to 6-8 times that of of regular coq10.

 

[me/cfs 27931]

200-300mg Ubiquinol a day for most of the past 2 years. It doesn't make any noticeable difference whether I take it or not. Not even a short term boost of energy.

 

[*GG*]

200-300mg Ubiquinol a day for most of the past 2 years. It doesn't make any noticeable difference whether I take it or not. Not even a short term boost of energy.[/QUOTE]

I am not sure it gives a boost of energy either, but perhaps lets me push myself without significant crashes? People would be amazed at how much I can exercise

GG

 

[Daffodil]

i took high doses cuz of myhill but found out it can lower BP...and i have low BP already

 

[Kierkegaard]

Thanks @ljimbo423!

So anyone have an idea of what the 1000-1500 mg of ubiquinone would come to in terms of ubiquinol?

 

[ljimbo423]

So anyone have an idea of what the 1000-1500 mg of ubiquinone would come to in terms of ubiquinol?

Here's a paper that says ubiquinol is 6-10 times more bioavailable than ubiquinone.

Studies have shown that the reduced form of CoQ10 known as Ubiquinol is 6–10 times more bioavailable than oxidized CoQ10 [3,4].

So if you average it out to 8 times more bioavailable, than1000-1500mg ubiquinone would equal 125-187 milligrams ubiquinol.

 

[drob31]

I have also noticed a PEM reducing effect of Q10, and I often take Q10 for this reason.

I find that you do not have to take Q10 daily to get this PEM-busting effect: you just need to take Q10 an hour before the exerting activity that you are about to partake in, and this I find prevents a lot of the PEM that you would normally experience when the activity is over. I use a dose of 400 mg of Q10 for this anti-PEM purpose.

I get ME/CFS PEM mainly from mental exertion (rarely from physical exertion), and for me, 3 or 4 hours of socializing with friends causes a lot of PEM the following day or two. However, if I take 400 mg of Q10 just before I begin this 3 or 4 hours of social activity, my PEM is noticeably reduced. Note that Q10 is most cheaply purchased in bulk powder form.


I also found two other medications with anti-PEM effects (ketoconazole 200 mg, and erythromycin 800 mg) but I am less sure about these, and I have to test them further before I can say for definite that they help minimize PEM.


PEM-busting supplements or drugs that you can take just before an exerting activity, so as to lower or prevent PEM, are really an unexplored area on this forum. I suspect there may be quite a few supplements and medications with anti-PEM effects, but nobody has properly noticed them.

In order to discover and identify any PEM-busting supplements, you would need to test them using an exerting activity you do on a regular basis, like say doing your regular weekend shopping (so that you know from past experience just how much PEM will arise from the activity), and then take a supplement like Q10 an hour before starting this regular activity, and see if you get less PEM than normal.

I know this is an old post, but I'm just connecting some dots:

https://selfhacked.com/2014/10/20/interleukin-6/

 

[Hip]

I know this is an old post, but I'm just connecting some dots:

https://selfhacked.com/2014/10/20/interleukin-6/

Care to share the dots you are connecting?

 

[drob31]

Care to share the dots you are connecting?

IL-6 is drastically elevated after certain types of exersize and it may be abnormally high in response to any activity for some. I think high levels of IL-6 are what is triggering PEM in some cases.

 

[Hip]

IL-6 is drastically elevated after certain types of exersize and it may be abnormally high in response to any activity for some. I think high levels of IL-6 are what is triggering PEM in some cases.

I was working on an IL-6 PEM theory some time ago (see this post and the subsequent posts), but it did not quite work out (the results of one study on PEM and IL-6 indicated that IL-6 was probably not involved).

The complexity with IL-6 is that IL-6 can operate by two pathways: the classical signaling IL-6 pathway which is anti-inflammatory and instigates tissue repair, and the trans-signaling IL-6 pathway which is pro-inflammatory.

So the IL-6 trans-signaling is the pathway that may cause problems, and is the pathway that is associated with cognitive dysfunction and neuroinflammation.

But a study showed that even just after exercise, ME/CFS patients IL-6 trans-signaling pathway was no higher than in healthy controls.

 

[drob31]

I was working on an IL-6 PEM theory some time ago (see this post and the subsequent posts), but it did not quite work out (the results of one study on PEM and IL-6 indicated that IL-6 was probably not involved).

The complexity with IL-6 is that IL-6 can operate by two pathways: the classical signaling IL-6 pathway which is anti-inflammatory and instigates tissue repair, and the trans-signaling IL-6 pathway which is pro-inflammatory.

So the IL-6 trans-signaling is the pathway that may cause problems, and is the pathway that is associated with cognitive dysfunction and neuroinflammation.

But a study showed that even just after exercise, ME/CFS patients IL-6 trans-signaling pathway was no higher than in healthy controls.

Wow that's cool to see we had the same train of thought, albeit mine was years behind. I wonder however, if a cytokine isn't still the culprit. Tnf-a, il2 b etc.