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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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You mean the interferons? It’s from lab4more (Dr. Bieger's lab). The EV test is from IMD Berlin. My EBV test in a local lab was non conclusive so I repeat it at IMD (Multiplex blot including EA, PCR was negative)
Have you done the Coxsackie B and Echovirus labs at ARUP?
If so, do they believe the immune system can cause it?
There is a lot of science on herpesviruses and EV. You just have to take it seriously... The very problem is the treatment! Because of immune exhaustionI suppose that if a virus was responsible for ME, I would expect to see much more supporting evidence from researchers and more verified success stories from antiviral treatments.
I don't really understand what this means. Can you be less metaphorical?
I know you haven't. You're a hard one to convince.No, I haven't been convinced that some sort of persistent viral infection is responsible for my ME
Yes @Wishful, the arup test will reveal all aspects of your ME, including pathophysiology, the cure, and a comprehensive interpretation of your astrological profileIf ME is caused by some sort of non-standard effect of a non-standard viral infection, such as semi-dormant viruses interfering with cellular mRNA, will the ARUP lab tests reveal it?
So very true. I don't think I do have this feeling.But the best description I have is the one you don't understand
Not sure i understand. Immune exhaustion from chronic infections or from the antivirals.There is a lot of science on herpesviruses and EV. You just have to take it seriously... The very problem is the treatment! Because of immune exhaustion
With high varicella titres, did you have chickenpox or an obvious shingles outbreak. Also possible to have internal shingles or mollarettes meningitis type of infections?Yep.
I have first very high titers for VZV (2018, when I became bedridden above 2000 now above 1200, so I think of a reactivation), and inconsistent findings around EBV and HHV-6 which i still investigate.
But the most obvious is Coxsackie B4 1:640 and related Interferon activity (look at my interferons and gene expression of interferons at Chia's presentation at IACFS/ME).
Furthermore very high titers for some mycotoxins and a bacterial overgrowth in kidneys or bladder, don’t know yet.
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Yes @Wishful, the arup test will reveal all aspects of your ME, including pathophysiology, the cure, and a comprehensive interpretation of your astrological profile
Yes, it's one thing to have a positive test result and another to know what that test result means.I expect that it also can't actually tell whether a detected virus is responsible for a given set of symptoms.
The problem is that if a virus is non-cytolytic like EV living in your cell or a herpesvirus that reactivates from time to time you won't get rid of it with antivirals. As long as you don't produce a sufficient amount of certain interferons (or have an infusion with is really too costly - like IFN lambda for EV - you won't get rid of it.But finding them and treating them is an issue. They don't appear in the blood in any traceable volume as they are local infections of certain cells and the body isn't putting up much of a fight (immune exhaustion?)
Well, actually, when Dr. Chia's looking at persistent EV infection in ME/CFS, he says about 1/3 have it in the blood.They don't appear in the blood in any traceable volume as they are local infections of certain cells
In the majority, it's an over-active immune response. Like, a constant fight against a very evasive virus. The overactive immune response is almost certainly a contributor to the autoimmunity seen in ME/CFS/LC.the body isn't putting up much of a fight (immune exhaustion?)
Didn't it say in Chia's latest presentation that it was only found in 1/3?Autopsy studies showed viral DNA in brains.