how a brain molecule could halt MS Feb 1, 2023


Senior Member

A researcher is one step closer to demonstrating the potential of a brain molecule called fractalkine to halt and even reverse the effects of multiple sclerosis and other neurodegenerative diseases. Researchers injected fractalkine into mice with chemically induced MS. They found the treatment increased the number of new oligodendrocytes -- vital brain and spinal cord cells that produce myelin in both embryonic and adult brains -- which are damaged during the MS autoimmune attack.

Voronova and her team observed new oligodendrocytes, as well as reactivated progenitor cells that can regenerate oligodendrocytes, in the brains of the treated animals. Remyelination occurred in both the white and grey matter. The researchers also observed a reduction in inflammation, part of the damage caused by the immune system. Next steps for the treatment include testing it in other diseased mouse models, including those with neurodegenerative diseases other than MS.