Hope I’m not late to the party - long Covid proves to be physical (article)

[Hope_eternal]

Just came across this article re Covid that proves the fatigue IS physical! Yay, it’s a great start! could long Covid findings help ME suffers?? I hope so.

https://www.msn.com/en-us/health/ot...p&cvid=2fac5a40620f40b6a9097d6d96b45403&ei=35

 

[mattie]

Here’s the complete article in PDF
And direct link to article: nature.com

 

[Rufous McKinney]

This is a significant new finding, but may not be entirely THE CAUSE...this could all be effects downstream of something else.

but its certainly vindicating for folks who experience severe muscular issues and find it very perplexing (my hip flexors)

 

[Hope_eternal]

Here’s the complete article in PDF
And direct link to article: nature.com

What I love about the findings is that they FINALLY prove that increasing exercise/physical activity is detrimental! I hope this gets fed to the health care providers so they stop shaming and blaming suffers!

 

[BrightCandle]

All they had to do was look, because patients have been reporting harm from exertion for decades. It's shameful it had to get this far before someone did muscle biopsies post exertion to prove the damage the patients were obviously reporting, I sure hope this puts a stop to the use of CPETs for diagnosis.

 

[andyguitar]

Here’s the complete article in PDF

Page 7 gives a fairly good description of what might be going, on and what might not. Amyloid deposits looks interesting-and what those deposits might contain. Pretty good bit of research.

 

[Murph]

Mods could we please bundle this thread into my thread on this paper ?
https://forums.phoenixrising.me/thr...in-long-covid-appelman-wust-et-al-2024.91340/

 

[Gijs]

Just came across this article re Covid that proves the fatigue IS physical! Yay, it’s a great start! could long Covid findings help ME suffers?? I hope so.

https://www.msn.com/en-us/health/ot...p&cvid=2fac5a40620f40b6a9097d6d96b45403&ei=35

N=25, not impressive at all. This study will not change anything for this moment. More replication studies are needed. Also it doesn't explain all symptoms and it is not the cause.

 

[Hope_eternal]

N=25, not impressive at all. This study will not change anything for this moment. More replication studies are needed. Also it doesn't explain all symptoms and it is not the cause.

Sorry you think it’s not impressive. I was happy they proved that the physical fatigue is biological. We were told like many to keep exercising and go see a psychiatrist numerous times. For 8 months the doctors looked at us like we were crazy and it was all mental. I think that this finding is very important to those that are dismissed by the medical community, I know it doesn’t explain all the symptoms unfortunately nor is it the cause but it does give those who were discounted some vindication. Next time that happens they can pull up the article and say nope you’re wrong.

 

[Rufous McKinney]

All they had to do was look

TADA

 

[Rufous McKinney]

Amyloid deposits looks interesting-and what those deposits might contain. Pretty good bit or research.

there are likely a few ways to go after these deposits.

 

[andyguitar]

there are likely a few ways to go after these deposits.

Fair bit of research that shows Amyloid can be broken down by Curcumin. Thought by some to have potential to treat Alzheimers.

 

[Wishful]

Fair bit of research that shows Amyloid can be broken down by Curcumin.

Check the wiki:

"Curcumin, which shows positive results in most drug discovery assays, is regarded as a false lead that medicinal chemists include among "pan-assay interference compounds". This attracts undue experimental attention while failing to advance as viable therapeutic or drug leads,[3][6][17] although some derivatives of curcumin such as EF-24 have seen a significant amount of research.[18]

Factors that limit the bioactivity of curcumin or its analogs include chemical instability, water insolubility, absence of potent and selective target activity, low bioavailability, limited tissue distribution, and extensive metabolism.[3] Very little curcumin escapes the GI tract and most is excreted in feces unchanged.[19] If curcumin enters plasma in reasonable amounts, there is a high risk of toxicity since it is promiscuous, and interacts with several proteins known to increase the risk of adverse effects, including hERG, cytochrome P450s, and glutathione S-transferase.[3]"

There's more about safety warnings.

 

[andyguitar]

Check the wiki:

Prefer checking research rather than Wiki. Like this,,,,,,,From 2022.

 

[andyguitar]

This is the full version of the above.