High levels of isoprostanes causes low blood volume?

[Emootje]

I'm hypovolemic and I tested very high on the urine isoprostane test. According to Dr. Bell these isoprostanes are the best candidates to cause low blood volume in CFS.
Anyone an idea how to lower these isoprostanes?

(9 -18min) ​

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[Emootje]

"F(2)-isoprostanes, however, were consistently higher in CFS patients"​

http://www.ncbi.nlm.nih.gov/pubmed/19422646​

"Patients with CFS also had significantly increased levels of CRP and 8-iso-prostaglandin F2α isoprostanes"​

http://www.ncbi.nlm.nih.gov/pubmed/18031285​

"Patients had significantly increased levels of isoprostanes"​

http://www.ncbi.nlm.nih.gov/pubmed/16085177​

 

[globalpilot]

Am I reading this correctly - your isoprostanes are 10x higher than the upper limit ?
I have had mine measured 3x at laboratoire phillip in France. I have been able to cut the levels in half by doing:
1. Rich's protocal
2. liposomal glutathione
3. vitamin E - tocotrienols and mixed tocopherols

I'm still over the top of the range though so going to add ALA.
You may already know this but isoprostane is a measure of oxidative damage to cell membranes (the fats) so you need fat soluble antioxidants for this.

 

[alex3619]

Hi globalpilot, yes you need fat soluble antioxidants, but antioxidants work in networks. Fat soluble antioxidants pass the radical damage onto water soluble antixidants for elimination. These transfers go back and forth. So while fat soluble antioxidants are important, so are water soluble antioxidants. I think ALA is both fat and water soluble, so it has some possibly unique properties. Bye, Alex

 

[globalpilot]

Thanks Alex, I understand and good point. I've had the water soluble (glutathione, pycnogenol, C, acai) on board for a while but was missing the fat soluble.

 

[Emootje]

Great - thanks for the helpful information.
My test was done at Medivere and they indeed found isoprostane levels 10 times higher than the upper limit. I'm already on a broad spectrum anti-oxidant regime (sulforaphane, NAC, vitamin E complex, taurine, ascorbicacid, beta-carotene, ubiquinol) and I'm now going to add ALA, BHT and liposomal glutathione. The lab also recommended a diet low in arachidonic acid (vegan diet) so no more animal products for me...

 

[Emootje]

Brassica vegetable consumption reduces urinary F2-isoprostane levels independent of micronutrient intake
"F2-iP levels significantly decreased by 22.0 or 21.8% during the BV intervention compared with Baseline or the M+F intervention"

 

[xchocoholic]

Thanks for posting this. Maybe this explains why my orthostatic hypotension went away one month
after I stopped eating so much meat and added more veggies. I was on the paleo diet and eating 1/4 lb
of meat per meal. In jan i switched to
the wahls diet.

I still have a bad case of pots tho. I get petite mals and sob if I'm up too long.

Hmm, I'm low on elastace and high on lcfas so my metametrix fat levels were off. I'm experimenting
with creon.

 

[Emootje]

Inflammatory diseases associated with high F2- isoprostanes:

Insights into Oxidative Stress: The Isoprostanes

 

[adreno]

Inflammatory diseases associated with high F2- isoprostanes:

Well, if isoprostanes are involved in all these diseases, it seems unlikely that they are the primary cause of OI.

 

[Emootje]

Good point Adreno!
There must be something more, but what?

 

[adreno]

Good point Adreno!
There must be something more, but what?

I wish I knew...

 

[August59]

Ecklonia Cava extract is a very good, strong fat soluble antioxidant. It alsso crosses the BBB and it also has a long half-life.

 

[Emootje]

Thanks August. I tried Ecklonia Cava and it made me feel slightly better