High-dose niacinamide fixed the mental and physical symptoms of a long COVID patient

Hip

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This Reddit post details how high-dose niacinamide (a form of vitamin B3) fixed the mental and physical symptoms of a long COVID patent

His long COVID mental symptoms included depression, tearful emotional instability, and anger.

His long COVID also included the symptoms of fatigue, brain fog, poor memory, nausea, body aches, neuropathy, eye floaters, dry eyes, and frequent urination.

He took niacinamide at a dose of 3,000 mg daily, and within a week started to feel better on all fronts. After 5 weeks on this niacinamide protocol, he returned to 90% of full health physically and mentally. He then reduced his niacinamide intake to 1,000 mg daily, and found his gains in health were still maintained.

At the time he started the niacinamide protocol, he had had long COVID for around 3 months. So of course his improvements might just be down to the natural process of recovery from post-viral fatigue.



In terms of studies linking vitamin B3 and COVID, one paper found that niacinamide might improve COVID-triggered kidney injury.

Other papers here and here say that COVID infection depletes the enzyme NAD+. Levels of this enzyme can be increased by taking vitamin B3, nicotinamide mononucleotide (NMN), or nicotinamide riboside (NR).



Note that higher doses of vitamin B3 can place strain on the liver, so it's normally recommended that you do not take more than 3,000 mg daily. If buying NMN, note that many NMN supplements are fraudulent and contain no NMN.
 
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kushami

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Boy, I wish I could have measured that person’s cerebral blood flow before, during and after.

At only three months, with the long waiting times and lack of awareness, it’s unlikely he had had an autonomic work-up or even done a NASA Lean Test.

Thanks for another interesting write up, @Hip.
 

mattie

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how to measure cerebral blood flow?

https://stichtingcardiozorg.nl/wp-c...-CBF-reduced-after-tilt-testing-in-mecrfs.pdf

Dr Visser / van Campen:

Using extracranial Doppler imaging of the carotid and vertebral
arteries, taking both flow velocity and vessel diameters into account,
we have demonstrated that cerebral blood flow is significantly
reduced in 90% of myalgic encephalomyelitis/chronic fatigue syn-
drome (ME/CFS) patients during a 70 degree tilt test

I was tested myself with this method and blood flow was seriously reduced both sitting and standing.
 
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Mary

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Note that higher doses of vitamin B3 can place strain on the liver, so it's normally recommended that you do not take more than 3,000 mg daily. If buying NMN, note that many NMN supplements are fraudulent and contain no NMN.

@Hip - many years ago my then-doctor told me that time-release niacin was linked to liver problems, because the liver was constantly being bathed in niacin due to "time-release". So he said to avoid time-release niacin and I would be fine. I'm guessing the same would be true for niacinamide.

He also said that 1000 mg a day was the upper safe limit for niacin. I don't know what he thought about niacinamide. Anyways, I've been taking around 800 mg. of niacin at night for many years - 500 mg. before bed and 300 mg. more middle of the night, and I've been fine. It does help me with sleep.
 

kushami

Senior Member
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458
@mattie , were you tested at Stichting Cardio Zorg?

I tried for a year to get this testing in Australia, but my specialist was really weird about it. I was finally booked in but he managed to sabotage it and I had to cancel. Exhausting.
 
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