• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To become a member, simply click the Register button at the top right.

Heterologous immunity: immunopathology, autoimmunity and protection during viral infections.


Senior Member
This piece is from 2011, but I couldn't find it on the forum here and the full text is interesting.

2011 Jun;44(4):328-47. doi: 10.3109/08916934.2011.523277. Epub 2011 Jan 20.
Heterologous immunity: immunopathology, autoimmunity and protection during viral infections.
Selin LK1, Wlodarczyk MF, Kraft AR, Nie S, Kenney LL, Puzone R, Celada F.
Author information
  • 1Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA. liisa.selin@umassmed.edu
Heterologous immunity is a common phenomenon present in all infections. Most of the time it is beneficial, mediating protective immunity, but in some individuals that have the wrong crossreactive response it leads to a cascade of events that result in severe immunopathology. Infections have been associated with autoimmune diseases such as diabetes, multiple sclerosis and lupus erythematosis, but also with unusual autoimmune like pathologies where the immune system appears dysregulated, such as, sarcoidosis, colitis, panniculitis, bronchiolitis obliterans, infectious mononucleosis and even chronic fatigue syndrome. Here we review the evidence that to better understand these autoreactive pathologies it requires an evaluation of how T cells are regulated and evolve during sequential infections with different pathogens under the influence of heterologous immunity.

PMID:21250837 [PubMed - indexed for MEDLINE] PMCID: PMC3633594