I'd like to understand Receptor Agonism.
Say, when you agonize dopamine receptors, you're not actually increasing dopamine amounts - what are you doing. I still don't quite grasp this concept. Are you:
Increasing the susceptibility and responsiveness of of existing receptors to your usual dopamine level?
Increasing the number of receptors?
I've recognized a considerable resolution of my symptoms during those dopamine moments that last only a few seconds (euphoria, feeling giddy because I accomplished something, a John Lennon song that suddenly makes me break down - most of his do). You know, those moments that give you a happy mushy lump in your throat.
And sexual activity.
And once I exit the POTS exasperating effect of alcohol by strictly pacing myself and keeping at it until I enter its euphoric dopaminergic stage. Doesn't last long though.
So I've been thinking about dopamine agonists, or even Abilify (especially since I read HIP mention somewhere here it can help with sensory gating).
I'm on 150 mg Zoloft, a dosage at which it's supposed to begin acting as a dopamine reuptake inhibitor, but it doesn't do anything, so I doubt the answer is reuptake inhibition, but rather receptor agonism. Otherwise they'd give Ritalin to Parkingsons patients.
But I don't quite grasp the concept.
Cheers,
Say, when you agonize dopamine receptors, you're not actually increasing dopamine amounts - what are you doing. I still don't quite grasp this concept. Are you:
Increasing the susceptibility and responsiveness of of existing receptors to your usual dopamine level?
Increasing the number of receptors?
I've recognized a considerable resolution of my symptoms during those dopamine moments that last only a few seconds (euphoria, feeling giddy because I accomplished something, a John Lennon song that suddenly makes me break down - most of his do). You know, those moments that give you a happy mushy lump in your throat.
And sexual activity.
And once I exit the POTS exasperating effect of alcohol by strictly pacing myself and keeping at it until I enter its euphoric dopaminergic stage. Doesn't last long though.
So I've been thinking about dopamine agonists, or even Abilify (especially since I read HIP mention somewhere here it can help with sensory gating).
I'm on 150 mg Zoloft, a dosage at which it's supposed to begin acting as a dopamine reuptake inhibitor, but it doesn't do anything, so I doubt the answer is reuptake inhibition, but rather receptor agonism. Otherwise they'd give Ritalin to Parkingsons patients.
But I don't quite grasp the concept.
Cheers,