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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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Have there been any animal studies for CFS?


Senior Member
Has anyone ever injected mice with blood from a CFS sufferer to see if they develop symptoms? Or to try to isolate a pathogen?


Senior Member
Dysautonomia International funded some work on antibodies thought to be related to POTS on rabbits. Some ME/CFS folks have POTS, and most have orthostatic intolerance.

Adrenergic Autoantibody-Induced Postural Tachycardia Syndrome in Rabbits, 2019, Li et al
Open access here: www.ahajournals.org/doi/10.1161/JAHA.119.013006
Editorial here: www.ahajournals.org/doi/10.1161/JAHA.119.014084

Dr Jose Montoya used to refer to a monkey model of CFS that was stopped when the researcher involved got CFS.

Gulf War illness now has many animal models - mostly by giving them a cocktail of drugs that those in the 1990 conflict were given.
Gulf War Illness Treatments Discovered. Will Veterans Affairs Officials Listen Now?

Most mouse models have been dubious such as this one
An Adrenalectomy Mouse Model Reflecting Clinical Features for Chronic Fatigue Syndrome

Some discussion on animal models on various s4me threads such as this one. Probably threads here too. I suggest you dig through those first if you have not already done so.