Have Scheibenbogen, Light, and Bergquist already cracked ME/CFS etiology?

[pattismith]

I still think this is a significant subset

I guess people having antibodies blocking acetylcholine receptors (muscarinic receptor) will have strong reaction to acetylcholine receptors blockers like promethazine,
Maybe it could explain partly @Wayne reaction to Phenergan?

 

[Jesse2233]

I guess people having antibodies blocking acetylcholine receptors (muscarinic receptor) will have strong reaction to acetylcholine receptors blockers like promethazine,
Maybe it could explain partly @Wayne reaction to Phenergan?

Yes good point

And they make good candidates for mestinon

 

[pattismith]

Yes good point

And they make good candidates for mestinon

People with polymorphism on acetylcholine receptors may well be more sensitive to these antibodies as well:

http://forums.phoenixrising.me/inde...e-receptors-in-chronic-fatigue-syndrom.37738/

 

[Gingergrrl]

And they make good candidates for mestinon

My case is so odd b/c I have the anti-muscarinic autoantibodies and yet I had a horrible reaction when I tried Mestinon in 2014. It seems that I require the perfect balance of acetylcholine (not too much or too little). I can tolerate IV Benadryl as a pre-med for Ritux (even two doses of it) but if I had to do this repeated days, I would develop a toxicity reaction. So meds at both ends of the spectrum (Mestinon and Benadryl as two examples) have to be in perfect balance. I am sure I am not explaining this well and it might not be adding anything helpful .

 

[pibee]

Having 8/9 positive and M4 even 7x increased (result 49 , range <7 ), others close, I tried only hurzapine A, with minor improvement, occassionally, sometimes I feel nothing.
From MCAS drugs (vit C, ranitidine, loratadine and quercetin, is what I tried so far) I have quite big benefit with my neurodevelopmental symptoms, brain fog etc, (hope i dont jinx it), as well as from antivirals (Valtrex).

CellTrend test is ELISA, and as @paolo explained in one of his post problem could be that it's not only to outer surface proteins but also inner surface receptor proteiins. But I still dont see a reason why would I be making very high autoantibodies to inner surface proteins?! Does this matter so much? I still dont get when or do autoantibodies penetrate cells sometimes?!

I also have Sjogrens and since M3 is found in 90% Sjogrens patients maybe this is why I am so high positive. But I got ME from mom's side, she has it, while Sjogren's is from dad's side - my aunt.

I'd prefer if these autoantibodies are significant but I dont believe in this much.

It is discouraging that Rituximab doesnt even work for Sjogren's fatigue.

But this all reminds me of autism findings - I listened to Dr Theo on MCAS, mentioned they find autoantibodies to brain in 30% of autistic kids, and those also have MCAS issues , allergies.
So 30% similar to ME case.