I've reported many times at PR my family's improvements (I don't buy there's a cure, yet).
Here is the PR activity scale for reference:
My uncle, who was about 7 on the PR activity scale, now gives every appearance of being cured. He is a very active 70-something -- dancing, playing softball, working part-time. He has no symptoms and currently takes no ME/CFS treatments. He did about 8 years of heavy-duty antivirals under an ME/CFS specialist.
My daughter was somewhere between a 4 and a 5 on the PR activity scale and heading downhill rapidly when she first saw an ME/CFS specialist. Two years of antivirals (both Valcyte and Valtrex) put her into what might be called a remission. She lives a fairly normal life. She's just finishing graduate school in engineering, is getting married next summer, travels to Europe once or twice a year and does the usual tourist stuff including plenty of walking, has been on several day-hiking vacations. She has not had a PEM episode in several years. She does not try to do competitive sports or aerobic exercise for the sake of exercise, so I couldn't say if that would result in PEM. She still takes a large number of symptomatic treatments and takes antivirals more often than not. I'd say she varies between 8 and 9 on the PR activity scale. She is not cured, but lives a fairly normal life, which is huge.
I was at a 1 on the PR activity scale when I first got antivirals from an ME/CFS specialist. That improved my condition to around 3 or 4 over the course of several years, but I was still largely housebound for another few years. I moved to another ME/CFS specialist with a broader range of treatments to see if we could tweak symptoms enough to get more functionality. Over the course of 2-3 more years we picked away at other symptoms and tried a number of additional treatments, none of which gave me the big improvement antivirals did, but each gave me another small increment of improvement. All those little increments continue to add up. Now I'm about a 7 on the PR activity scale. I work full-time at a physically easy job, and take care of myself and my house, but I can't do much else. For example, moving recently pushed me into a PEM episode (my first in more than 6 months), but it was milder than previous episodes and I recovered more quickly than previously (about 10 days).
I continue to take a lot of treatments to maintain this level of functionality. This is definitely not cured or a remission. It's keeping up with activity management and a lot of symptomatic treatments to offset the symptoms of the illness. But being able to work full-time, socialize mildly, go grocery shopping without a cart/wheelchair, and so on, is FAR better than laying in bed, unable even to read, staring out the window.
My family has benefited greatly from seeing top ME/CFS specialists. For me and my daughter, treatment from top ME/CFS specialists made the difference between having no life and something resembling normal life. It's not 100%. It requires a massive amount of determination to keep up with all the treatments. It did not happen over night. I cannot emphasize that last too much -- significant improvement did not happen over night. It took years to get where we are now. It's a long, hard haul to get significant improvement, but well worth it to have a large chunk of life back.